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The effect of Tołpa Peat Preparation on the phagocytic and metabolic activity of neutrophils in normothermic rabbits and with pyrogen-induced fever.
Acta Pol Pharm 1993; 50(4-5):389-92AP

Abstract

The studies on normothermic rabbits show that intravenous administration of Tołpa Peat Preparation (TPP) at a dose of 5 mg/kg for 3 or 6 consecutive days increases the percentage of phagocytizing cells and the number of bacteria phagocytized by a single neutrophil. The stimulated phagocytic activity of neutrophils coincides with increased nitroblue tetrazolium (NBT) reduction. In contrast, a single administration of TPP to rabbits with fever induced by E.coli lipopolysaccharide (LPS) has a modulating effect on the metabolic activity of neutrophils, depending on TPP dose. TPP administered at a dose of 0.5 mg/kg potentiates the stimulating effect of pyrogen on the percent of NBT-positive neutrophils. A tenfold increase of TPP dose (5 mg/kg) reduces the stimulating effect of LPS and a hundredfold increase (50 mg/kg) leads to total inhibition of LPS-induced changes.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Agricultural University, Wrocław, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8036926

Citation

Obmińska-Domoradzka, B, et al. "The Effect of Tołpa Peat Preparation On the Phagocytic and Metabolic Activity of Neutrophils in Normothermic Rabbits and With Pyrogen-induced Fever." Acta Poloniae Pharmaceutica, vol. 50, no. 4-5, 1993, pp. 389-92.
Obmińska-Domoradzka B, Switała M, Debowy J, et al. The effect of Tołpa Peat Preparation on the phagocytic and metabolic activity of neutrophils in normothermic rabbits and with pyrogen-induced fever. Acta Pol Pharm. 1993;50(4-5):389-92.
Obmińska-Domoradzka, B., Switała, M., Debowy, J., & Garbuliński, T. (1993). The effect of Tołpa Peat Preparation on the phagocytic and metabolic activity of neutrophils in normothermic rabbits and with pyrogen-induced fever. Acta Poloniae Pharmaceutica, 50(4-5), pp. 389-92.
Obmińska-Domoradzka B, et al. The Effect of Tołpa Peat Preparation On the Phagocytic and Metabolic Activity of Neutrophils in Normothermic Rabbits and With Pyrogen-induced Fever. Acta Pol Pharm. 1993;50(4-5):389-92. PubMed PMID: 8036926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Tołpa Peat Preparation on the phagocytic and metabolic activity of neutrophils in normothermic rabbits and with pyrogen-induced fever. AU - Obmińska-Domoradzka,B, AU - Switała,M, AU - Debowy,J, AU - Garbuliński,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 389 EP - 92 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 4-5 N2 - The studies on normothermic rabbits show that intravenous administration of Tołpa Peat Preparation (TPP) at a dose of 5 mg/kg for 3 or 6 consecutive days increases the percentage of phagocytizing cells and the number of bacteria phagocytized by a single neutrophil. The stimulated phagocytic activity of neutrophils coincides with increased nitroblue tetrazolium (NBT) reduction. In contrast, a single administration of TPP to rabbits with fever induced by E.coli lipopolysaccharide (LPS) has a modulating effect on the metabolic activity of neutrophils, depending on TPP dose. TPP administered at a dose of 0.5 mg/kg potentiates the stimulating effect of pyrogen on the percent of NBT-positive neutrophils. A tenfold increase of TPP dose (5 mg/kg) reduces the stimulating effect of LPS and a hundredfold increase (50 mg/kg) leads to total inhibition of LPS-induced changes. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/8036926/The_effect_of_Tołpa_Peat_Preparation_on_the_phagocytic_and_metabolic_activity_of_neutrophils_in_normothermic_rabbits_and_with_pyrogen_induced_fever_ L2 - https://medlineplus.gov/fever.html DB - PRIME DP - Unbound Medicine ER -