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The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. I. Morphological changes in the thymus.
Acta Pol Pharm 1993; 50(4-5):397-404AP

Abstract

In experiment I BALB/c 200 mice were given in drinking water the TPP (Tołpa Peat Preparation) in daily doses of 1, 10 and 50 mg/kg over the period of 3, 5, 7, 9 and 12 weeks. In experiment II before the administration of TPP (as in experiment I) mice were immunized with a single dose i.p. administration of 0.2 cm3 of a 10% suspension of sheep erythrocytes (SRBC), i.e. 4 x 10(8) cells. Histopathological and ultrastructural studies have shown that TPP in all three doses causes morphological changes characteristic of thymus activity stimulation. However, the doses of 10 and 50 mg/kg administered longer than 7 weeks caused retrograde changes that did not occur after administration of 1 mg/kg of TPP. Morphological changes in the thymus of immunized and non-immunized mice simultaneously receiving TPP were similar.

Authors+Show Affiliations

Department of Pathological Anatomy and Forensic Veterinary, Agriculture University, Wrocław, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8036928

Citation

Madej, J A., et al. "The Influence of Long-term Administration of Tołpa Peat Preparation On Immune Reactivity in Mice. I. Morphological Changes in the Thymus." Acta Poloniae Pharmaceutica, vol. 50, no. 4-5, 1993, pp. 397-404.
Madej JA, Kuryszko J, Garbuliński T. The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. I. Morphological changes in the thymus. Acta Pol Pharm. 1993;50(4-5):397-404.
Madej, J. A., Kuryszko, J., & Garbuliński, T. (1993). The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. I. Morphological changes in the thymus. Acta Poloniae Pharmaceutica, 50(4-5), pp. 397-404.
Madej JA, Kuryszko J, Garbuliński T. The Influence of Long-term Administration of Tołpa Peat Preparation On Immune Reactivity in Mice. I. Morphological Changes in the Thymus. Acta Pol Pharm. 1993;50(4-5):397-404. PubMed PMID: 8036928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. I. Morphological changes in the thymus. AU - Madej,J A, AU - Kuryszko,J, AU - Garbuliński,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 397 EP - 404 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 4-5 N2 - In experiment I BALB/c 200 mice were given in drinking water the TPP (Tołpa Peat Preparation) in daily doses of 1, 10 and 50 mg/kg over the period of 3, 5, 7, 9 and 12 weeks. In experiment II before the administration of TPP (as in experiment I) mice were immunized with a single dose i.p. administration of 0.2 cm3 of a 10% suspension of sheep erythrocytes (SRBC), i.e. 4 x 10(8) cells. Histopathological and ultrastructural studies have shown that TPP in all three doses causes morphological changes characteristic of thymus activity stimulation. However, the doses of 10 and 50 mg/kg administered longer than 7 weeks caused retrograde changes that did not occur after administration of 1 mg/kg of TPP. Morphological changes in the thymus of immunized and non-immunized mice simultaneously receiving TPP were similar. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/8036928/The_influence_of_long_term_administration_of_Tołpa_Peat_Preparation_on_immune_reactivity_in_mice__I__Morphological_changes_in_the_thymus_ DB - PRIME DP - Unbound Medicine ER -