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The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. II. The effect of intermittent TPP administration on the morphological picture of lymphatic organs.
Acta Pol Pharm 1993; 50(4-5):405-8AP

Abstract

The studies were conducted on 200 Balb/c mice (inbred strain), aged 8 weeks. The mice were administered Tołpa Peat Preparation (TPP) in drinking water (10 or 50 mg/kg/day) for seven weeks (experiment I). Two lobes of the thymus, the spleen and the axillary and mesenteric lymph nodes of mice were taken for histological examinations after 3, 5 and 7 weeks of continuous TPP treatment and also 12 and 16 weeks from the beginning of the treatment. In experiment II, TPP was administered daily at the same doses for 3 weeks, and intermittently for 9 consecutive weeks; a week interval followed each seven-day cycle. The lymphatic organs of mice were taken for histological examinations after 3, 5, 7, 9 and 12 weeks of TPP treatment. It was found that daily administration of TPP (as described above) to mice for 7 weeks (10 mg/kg) induced a marked stimulation of the lymphatic organs (in the first weeks of TPP treatment) and resulted in retrograde changes (depletion of thymocytes and lymphocytes) in the lymphatic structures when TPP administration was prolonged (4-7 weeks). The morphological changes due to TPP administered at the dose of 50 mg/kg were less pronounced in the organs examined. The retrograde changes in the lymphatic structures disappeared 9 weeks after TPP treatment had been stopped. Similarly, the changes showing stimulation of the lymphatic organs were maintained throughout the entire period of 9 weeks.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pathological Anatomy and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, Agriculture University, Wrocław, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8036929

Citation

Madej, J A., et al. "The Influence of Long-term Administration of Tołpa Peat Preparation On Immune Reactivity in Mice. II. the Effect of Intermittent TPP Administration On the Morphological Picture of Lymphatic Organs." Acta Poloniae Pharmaceutica, vol. 50, no. 4-5, 1993, pp. 405-8.
Madej JA, Obmińska-Domoradzka B, Garbuliński T. The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. II. The effect of intermittent TPP administration on the morphological picture of lymphatic organs. Acta Pol Pharm. 1993;50(4-5):405-8.
Madej, J. A., Obmińska-Domoradzka, B., & Garbuliński, T. (1993). The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. II. The effect of intermittent TPP administration on the morphological picture of lymphatic organs. Acta Poloniae Pharmaceutica, 50(4-5), pp. 405-8.
Madej JA, Obmińska-Domoradzka B, Garbuliński T. The Influence of Long-term Administration of Tołpa Peat Preparation On Immune Reactivity in Mice. II. the Effect of Intermittent TPP Administration On the Morphological Picture of Lymphatic Organs. Acta Pol Pharm. 1993;50(4-5):405-8. PubMed PMID: 8036929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. II. The effect of intermittent TPP administration on the morphological picture of lymphatic organs. AU - Madej,J A, AU - Obmińska-Domoradzka,B, AU - Garbuliński,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 405 EP - 8 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 4-5 N2 - The studies were conducted on 200 Balb/c mice (inbred strain), aged 8 weeks. The mice were administered Tołpa Peat Preparation (TPP) in drinking water (10 or 50 mg/kg/day) for seven weeks (experiment I). Two lobes of the thymus, the spleen and the axillary and mesenteric lymph nodes of mice were taken for histological examinations after 3, 5 and 7 weeks of continuous TPP treatment and also 12 and 16 weeks from the beginning of the treatment. In experiment II, TPP was administered daily at the same doses for 3 weeks, and intermittently for 9 consecutive weeks; a week interval followed each seven-day cycle. The lymphatic organs of mice were taken for histological examinations after 3, 5, 7, 9 and 12 weeks of TPP treatment. It was found that daily administration of TPP (as described above) to mice for 7 weeks (10 mg/kg) induced a marked stimulation of the lymphatic organs (in the first weeks of TPP treatment) and resulted in retrograde changes (depletion of thymocytes and lymphocytes) in the lymphatic structures when TPP administration was prolonged (4-7 weeks). The morphological changes due to TPP administered at the dose of 50 mg/kg were less pronounced in the organs examined. The retrograde changes in the lymphatic structures disappeared 9 weeks after TPP treatment had been stopped. Similarly, the changes showing stimulation of the lymphatic organs were maintained throughout the entire period of 9 weeks.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/8036929/The_influence_of_long_term_administration_of_Tołpa_Peat_Preparation_on_immune_reactivity_in_mice__II__The_effect_of_intermittent_TPP_administration_on_the_morphological_picture_of_lymphatic_organs_ DB - PRIME DP - Unbound Medicine ER -