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Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.
Hypertension. 1994 Aug; 24(2):183-8.H

Abstract

We have previously shown that the endothelin content in arteries of deoxycorticosterone acetate (DOCA)-salt hypertensive rats is increased. We designed this study to examine, using the new orally active nonselective endothelin receptor antagonist bosentan, whether this increase in vascular endothelin may contribute to elevated blood pressure and vascular hypertrophy in DOCA-salt hypertensive rats. Rats received bosentan (100 mg/kg body wt per day) for 3 weeks mixed with their food. Systolic blood pressure of DOCA-salt hypertensive rats rose to 197 +/- 5 mm Hg, and that of bosentan-treated DOCA-salt hypertensive rats was 177 +/- 4 mm Hg (P < .01). Mesenteric resistance arteries were studied on a wire myograph. The media width, ratio of media width to lumen diameter, and cross-sectional area of the media of resistance arteries of bosentan-treated DOCA-salt hypertensive rats were significantly smaller than those of untreated DOCA-salt hypertensive rats. The lumen diameter and cross-sectional area of the media of vessels of bosentan-treated rats were not different from those of uninephrectomized control rats. Vasoconstrictor responses, which were altered in DOCA-salt hypertensive rats, approached control in the bosentan-treated rats. We conclude that these results with a nonselective endothelin receptor antagonist may suggest a role for endothelin in the elevation of blood pressure and vascular hypertrophy and remodeling in DOCA-salt hypertensive rats.

Authors+Show Affiliations

Clinical Research Institute of Montreal, University of Montreal, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8039842

Citation

Li, J S., et al. "Effect of a Nonselective Endothelin Antagonist On Vascular Remodeling in Deoxycorticosterone Acetate-salt Hypertensive Rats. Evidence for a Role of Endothelin in Vascular Hypertrophy." Hypertension (Dallas, Tex. : 1979), vol. 24, no. 2, 1994, pp. 183-8.
Li JS, Larivière R, Schiffrin EL. Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. Hypertension. 1994;24(2):183-8.
Li, J. S., Larivière, R., & Schiffrin, E. L. (1994). Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. Hypertension (Dallas, Tex. : 1979), 24(2), 183-8.
Li JS, Larivière R, Schiffrin EL. Effect of a Nonselective Endothelin Antagonist On Vascular Remodeling in Deoxycorticosterone Acetate-salt Hypertensive Rats. Evidence for a Role of Endothelin in Vascular Hypertrophy. Hypertension. 1994;24(2):183-8. PubMed PMID: 8039842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. AU - Li,J S, AU - Larivière,R, AU - Schiffrin,E L, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 183 EP - 8 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 24 IS - 2 N2 - We have previously shown that the endothelin content in arteries of deoxycorticosterone acetate (DOCA)-salt hypertensive rats is increased. We designed this study to examine, using the new orally active nonselective endothelin receptor antagonist bosentan, whether this increase in vascular endothelin may contribute to elevated blood pressure and vascular hypertrophy in DOCA-salt hypertensive rats. Rats received bosentan (100 mg/kg body wt per day) for 3 weeks mixed with their food. Systolic blood pressure of DOCA-salt hypertensive rats rose to 197 +/- 5 mm Hg, and that of bosentan-treated DOCA-salt hypertensive rats was 177 +/- 4 mm Hg (P < .01). Mesenteric resistance arteries were studied on a wire myograph. The media width, ratio of media width to lumen diameter, and cross-sectional area of the media of resistance arteries of bosentan-treated DOCA-salt hypertensive rats were significantly smaller than those of untreated DOCA-salt hypertensive rats. The lumen diameter and cross-sectional area of the media of vessels of bosentan-treated rats were not different from those of uninephrectomized control rats. Vasoconstrictor responses, which were altered in DOCA-salt hypertensive rats, approached control in the bosentan-treated rats. We conclude that these results with a nonselective endothelin receptor antagonist may suggest a role for endothelin in the elevation of blood pressure and vascular hypertrophy and remodeling in DOCA-salt hypertensive rats. SN - 0194-911X UR - https://www.unboundmedicine.com/medline/citation/8039842/Effect_of_a_nonselective_endothelin_antagonist_on_vascular_remodeling_in_deoxycorticosterone_acetate_salt_hypertensive_rats__Evidence_for_a_role_of_endothelin_in_vascular_hypertrophy_ L2 - https://www.ahajournals.org/doi/10.1161/01.hyp.24.2.183?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -