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Difference in frequencies of the cystic fibrosis alleles, delta F508 and W1282X, between carriers and patients.

Abstract

One major mutation, delta F508, causing cystic fibrosis (CF) is found in most populations around the world. Among CF patients of Jewish Ashkenazi origin two major mutations, W1282X and delta F508 were found. We compared the relative frequencies of the two major mutations found in this patient population to their relative frequencies in the healthy population. The studied patient population included the entire CF Jewish Ashkenazi patient population in Israel (238 chromosomes), and a small group of Jewish Ashkenazi patients in the USA (57 chromosomes). Among these, 79 (27%) chromosomes carried the delta F508 mutation, and 151 (51%) the W1282X mutation. In addition, we have analyzed the results of screening 1,946 unrelated healthy Jewish Ashkenazi individuals for the delta F508 and the W1282X mutations. Surprisingly, an almost equal number of carriers of the delta F508 (35) and W1282X (36) was found. The difference between the relative proportions of the mutations in the two groups is statistically significant (p = 0.025). A striking manifestation of this difference is revealed in the analysis of patients' genotypes. There were 36 patients homozygous for W1282X, while only 7 patients were homozygous for delta F508, although the number of delta F508 carriers in the general Jewish Ashkenazi population is almost equal to the number of W1282X carriers. This difference in allele frequencies found between healthy carriers and CF patients in the Jewish Ashkenazi population might not be unique to this ethnic group nor to the CF disease. The results indicate that the common practice of inferring general population epidemiologic parameters directly from patients information is liable to introduce biases.(

ABSTRACT

TRUNCATED AT 250 WORDS)

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Authors+Show Affiliations

,

Department of Genetics, Silberman Life Sciences Institute, Hebrew University of Jerusalem, Israel.

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Source

MeSH

Adult
Alleles
Bias
Child
Cystic Fibrosis
Gene Frequency
Genetic Carrier Screening
Genotype
Heterozygote
Homozygote
Humans
Israel
Jews
Molecular Epidemiology
Mutation
Phenotype
Reproducibility of Results
United States

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8044659

Citation

TY - JOUR T1 - Difference in frequencies of the cystic fibrosis alleles, delta F508 and W1282X, between carriers and patients. AU - Kalman,Y M, AU - Kerem,E, AU - Darvasi,A, AU - DeMarchi,J, AU - Kerem,B, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 77 EP - 82 JF - European journal of human genetics : EJHG JO - Eur. J. Hum. Genet. VL - 2 IS - 2 N2 - One major mutation, delta F508, causing cystic fibrosis (CF) is found in most populations around the world. Among CF patients of Jewish Ashkenazi origin two major mutations, W1282X and delta F508 were found. We compared the relative frequencies of the two major mutations found in this patient population to their relative frequencies in the healthy population. The studied patient population included the entire CF Jewish Ashkenazi patient population in Israel (238 chromosomes), and a small group of Jewish Ashkenazi patients in the USA (57 chromosomes). Among these, 79 (27%) chromosomes carried the delta F508 mutation, and 151 (51%) the W1282X mutation. In addition, we have analyzed the results of screening 1,946 unrelated healthy Jewish Ashkenazi individuals for the delta F508 and the W1282X mutations. Surprisingly, an almost equal number of carriers of the delta F508 (35) and W1282X (36) was found. The difference between the relative proportions of the mutations in the two groups is statistically significant (p = 0.025). A striking manifestation of this difference is revealed in the analysis of patients' genotypes. There were 36 patients homozygous for W1282X, while only 7 patients were homozygous for delta F508, although the number of delta F508 carriers in the general Jewish Ashkenazi population is almost equal to the number of W1282X carriers. This difference in allele frequencies found between healthy carriers and CF patients in the Jewish Ashkenazi population might not be unique to this ethnic group nor to the CF disease. The results indicate that the common practice of inferring general population epidemiologic parameters directly from patients information is liable to introduce biases.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1018-4813 UR - https://www.unboundmedicine.com/medline/citation/8044659/Difference_in_frequencies_of_the_cystic_fibrosis_alleles_delta_F508_and_W1282X_between_carriers_and_patients_ L2 - http://www.diseaseinfosearch.org/result/2071 ER -