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The short-term effects of conjugated estrogen on bone turnover in older women.
J Clin Endocrinol Metab. 1994 Aug; 79(2):366-71.JC

Abstract

Estrogen replacement therapy (ERT) prevents bone loss and fracture in early postmenopausal women, but its benefit for women over 70 yr of age has not been determined. We have examined the effect of a short course of ERT on biochemical markers of bone turnover in older women. Eleven women (mean age, 77 yr) were given conjugated estrogen (Premarin; 0.625 mg/day) for 6 weeks. Biochemical markers were measured on serum and urine collected at baseline (two samples), after 5 and 6 weeks of ERT, and 5 and 6 weeks post-ERT. Markers of bone formation were osteocalcin, bone alkaline phosphatase, and type I procollagen peptide. Markers of bone resorption were total urinary hydroxyproline, total and free pyridinoline and deoxypyridinoline cross-links, type I collagen cross-linked N-telopeptides, and serum C-terminal cross-linked telopeptide. Data were analyzed by repeated measures multivariate analysis of variance to estimate the overall effect of ERT on the biochemical markers. Markers of bone resorption decreased during ERT and returned to baseline after ERT (P < 0.05). Markers of bone formation declined less during ERT and continued to decline after ERT (P < 0.05). We conclude that ERT reduces bone turnover in older women and that markers of bone turnover may be useful in assessing the response to treatment in this age group.

Authors+Show Affiliations

Travelers Center on Aging, University of Connecticut Health Center, Farmington 06030.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8045949

Citation

Prestwood, K M., et al. "The Short-term Effects of Conjugated Estrogen On Bone Turnover in Older Women." The Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 2, 1994, pp. 366-71.
Prestwood KM, Pilbeam CC, Burleson JA, et al. The short-term effects of conjugated estrogen on bone turnover in older women. J Clin Endocrinol Metab. 1994;79(2):366-71.
Prestwood, K. M., Pilbeam, C. C., Burleson, J. A., Woodiel, F. N., Delmas, P. D., Deftos, L. J., & Raisz, L. G. (1994). The short-term effects of conjugated estrogen on bone turnover in older women. The Journal of Clinical Endocrinology and Metabolism, 79(2), 366-71.
Prestwood KM, et al. The Short-term Effects of Conjugated Estrogen On Bone Turnover in Older Women. J Clin Endocrinol Metab. 1994;79(2):366-71. PubMed PMID: 8045949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The short-term effects of conjugated estrogen on bone turnover in older women. AU - Prestwood,K M, AU - Pilbeam,C C, AU - Burleson,J A, AU - Woodiel,F N, AU - Delmas,P D, AU - Deftos,L J, AU - Raisz,L G, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 366 EP - 71 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 79 IS - 2 N2 - Estrogen replacement therapy (ERT) prevents bone loss and fracture in early postmenopausal women, but its benefit for women over 70 yr of age has not been determined. We have examined the effect of a short course of ERT on biochemical markers of bone turnover in older women. Eleven women (mean age, 77 yr) were given conjugated estrogen (Premarin; 0.625 mg/day) for 6 weeks. Biochemical markers were measured on serum and urine collected at baseline (two samples), after 5 and 6 weeks of ERT, and 5 and 6 weeks post-ERT. Markers of bone formation were osteocalcin, bone alkaline phosphatase, and type I procollagen peptide. Markers of bone resorption were total urinary hydroxyproline, total and free pyridinoline and deoxypyridinoline cross-links, type I collagen cross-linked N-telopeptides, and serum C-terminal cross-linked telopeptide. Data were analyzed by repeated measures multivariate analysis of variance to estimate the overall effect of ERT on the biochemical markers. Markers of bone resorption decreased during ERT and returned to baseline after ERT (P < 0.05). Markers of bone formation declined less during ERT and continued to decline after ERT (P < 0.05). We conclude that ERT reduces bone turnover in older women and that markers of bone turnover may be useful in assessing the response to treatment in this age group. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/8045949/The_short_term_effects_of_conjugated_estrogen_on_bone_turnover_in_older_women_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.79.2.8045949 DB - PRIME DP - Unbound Medicine ER -