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Emergence of gram-negative bacilli in the mouths of bone marrow transplant recipients using chlorhexidine mouthrinse.
Oncol Nurs Forum. 1994 May; 21(4):691-6.ON

Abstract

PURPOSE/OBJECTIVES

To examine whether use of chlorhexidine (CHX) in stomatitis-prevention regimens following bone marrow transplantation (BMT) enhances the emergence of gram-negative bacilli (GNB) to a degree that exceeds its benefits.

DATA SOURCES

Articles, book chapters, and case studies.

DATA SYNTHESIS

Despite rigorous topical and systemic antimicrobial therapy, oral opportunistic GNB infections occur following BMT. This is most likely because of low susceptibility of GNB to CHX and not that CHX predisposes patients to these infections or the development of CHX resistant strains.

CONCLUSIONS

The benefits of CHX use (e.g. preservation of oral mucosa and broad-spectrum antibacterial and antifungal effects) outweight the risks of GNB infection.

IMPLICATIONS FOR NURSING PRACTICE

Routine clinical and microbiologic monitoring of the oral cavity are essential with use of CHX. Stomatitis care standards and patient instructions following discharge are included.

Authors+Show Affiliations

Department of Oral Health Practice, University of Kentucky in Lexington.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8047467

Citation

Raybould, T P., et al. "Emergence of Gram-negative Bacilli in the Mouths of Bone Marrow Transplant Recipients Using Chlorhexidine Mouthrinse." Oncology Nursing Forum, vol. 21, no. 4, 1994, pp. 691-6.
Raybould TP, Carpenter AD, Ferretti GA, et al. Emergence of gram-negative bacilli in the mouths of bone marrow transplant recipients using chlorhexidine mouthrinse. Oncol Nurs Forum. 1994;21(4):691-6.
Raybould, T. P., Carpenter, A. D., Ferretti, G. A., Brown, A. T., Lillich, T. T., & Henslee, J. (1994). Emergence of gram-negative bacilli in the mouths of bone marrow transplant recipients using chlorhexidine mouthrinse. Oncology Nursing Forum, 21(4), 691-6.
Raybould TP, et al. Emergence of Gram-negative Bacilli in the Mouths of Bone Marrow Transplant Recipients Using Chlorhexidine Mouthrinse. Oncol Nurs Forum. 1994;21(4):691-6. PubMed PMID: 8047467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emergence of gram-negative bacilli in the mouths of bone marrow transplant recipients using chlorhexidine mouthrinse. AU - Raybould,T P, AU - Carpenter,A D, AU - Ferretti,G A, AU - Brown,A T, AU - Lillich,T T, AU - Henslee,J, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 691 EP - 6 JF - Oncology nursing forum JO - Oncol Nurs Forum VL - 21 IS - 4 N2 - PURPOSE/OBJECTIVES: To examine whether use of chlorhexidine (CHX) in stomatitis-prevention regimens following bone marrow transplantation (BMT) enhances the emergence of gram-negative bacilli (GNB) to a degree that exceeds its benefits. DATA SOURCES: Articles, book chapters, and case studies. DATA SYNTHESIS: Despite rigorous topical and systemic antimicrobial therapy, oral opportunistic GNB infections occur following BMT. This is most likely because of low susceptibility of GNB to CHX and not that CHX predisposes patients to these infections or the development of CHX resistant strains. CONCLUSIONS: The benefits of CHX use (e.g. preservation of oral mucosa and broad-spectrum antibacterial and antifungal effects) outweight the risks of GNB infection. IMPLICATIONS FOR NURSING PRACTICE: Routine clinical and microbiologic monitoring of the oral cavity are essential with use of CHX. Stomatitis care standards and patient instructions following discharge are included. SN - 0190-535X UR - https://www.unboundmedicine.com/medline/citation/8047467/Emergence_of_gram_negative_bacilli_in_the_mouths_of_bone_marrow_transplant_recipients_using_chlorhexidine_mouthrinse_ L2 - https://medlineplus.gov/bonemarrowtransplantation.html DB - PRIME DP - Unbound Medicine ER -