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Efficacy of omeprazole in lower grades of gastro-oesophageal reflux disease.
Scand J Gastroenterol Suppl. 1994; 201:69-73.SJ

Abstract

Grade I oesophagitis is usually considered to be a less severe form of gastro-oesophageal reflux disease (GORD). However, with regard to symptom severity, patients without macroscopic mucosal lesions have been shown not to differ from those with more severe oesophagitis. A number of controlled trials on the efficacy of omeprazole in GORD have included patients with lower grades of the disease. The results show that the differences in efficacy between omeprazole and H2-receptor antagonists, which have been established for the treatment of erosive and ulcerative oesophagitis, also extend to patients with grade I oesophagitis (erythema and friability). In these studies, omeprazole provided more rapid symptom resolution and histological improvement than ranitidine. In one double-blind comparative trial, complete endoscopic normalization of the oesophageal mucosa was observed in 90% of patients with grade I oesophagitis within 4 weeks of treatment with omeprazole, 40 mg once daily, compared with 55% of those treated with ranitidine, 150 mg twice daily; at 8 weeks the mucosa in all patients in the omeprazole group had completely healed at endoscopy, while oesophagitis was still present in 21% of the patients receiving ranitidine. A separate 6-month, placebo-controlled maintenance study was performed in patients who had completed a short-term study and who had total relief from the major symptoms of GORD and complete healing of endoscopic oesophagitis. All patients given placebo had an endoscopic recurrence (i.e. endoscopic grade I or more) and this was associated with the return of symptoms in 75% of cases.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Dept. of Medical Gastroenterology, Odense University Hospital, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

8047827

Citation

Havelund, T, et al. "Efficacy of Omeprazole in Lower Grades of Gastro-oesophageal Reflux Disease." Scandinavian Journal of Gastroenterology. Supplement, vol. 201, 1994, pp. 69-73.
Havelund T, Laursen LS, Lauritsen K. Efficacy of omeprazole in lower grades of gastro-oesophageal reflux disease. Scand J Gastroenterol Suppl. 1994;201:69-73.
Havelund, T., Laursen, L. S., & Lauritsen, K. (1994). Efficacy of omeprazole in lower grades of gastro-oesophageal reflux disease. Scandinavian Journal of Gastroenterology. Supplement, 201, 69-73.
Havelund T, Laursen LS, Lauritsen K. Efficacy of Omeprazole in Lower Grades of Gastro-oesophageal Reflux Disease. Scand J Gastroenterol Suppl. 1994;201:69-73. PubMed PMID: 8047827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of omeprazole in lower grades of gastro-oesophageal reflux disease. AU - Havelund,T, AU - Laursen,L S, AU - Lauritsen,K, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 69 EP - 73 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand J Gastroenterol Suppl VL - 201 N2 - Grade I oesophagitis is usually considered to be a less severe form of gastro-oesophageal reflux disease (GORD). However, with regard to symptom severity, patients without macroscopic mucosal lesions have been shown not to differ from those with more severe oesophagitis. A number of controlled trials on the efficacy of omeprazole in GORD have included patients with lower grades of the disease. The results show that the differences in efficacy between omeprazole and H2-receptor antagonists, which have been established for the treatment of erosive and ulcerative oesophagitis, also extend to patients with grade I oesophagitis (erythema and friability). In these studies, omeprazole provided more rapid symptom resolution and histological improvement than ranitidine. In one double-blind comparative trial, complete endoscopic normalization of the oesophageal mucosa was observed in 90% of patients with grade I oesophagitis within 4 weeks of treatment with omeprazole, 40 mg once daily, compared with 55% of those treated with ranitidine, 150 mg twice daily; at 8 weeks the mucosa in all patients in the omeprazole group had completely healed at endoscopy, while oesophagitis was still present in 21% of the patients receiving ranitidine. A separate 6-month, placebo-controlled maintenance study was performed in patients who had completed a short-term study and who had total relief from the major symptoms of GORD and complete healing of endoscopic oesophagitis. All patients given placebo had an endoscopic recurrence (i.e. endoscopic grade I or more) and this was associated with the return of symptoms in 75% of cases.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/8047827/Efficacy_of_omeprazole_in_lower_grades_of_gastro_oesophageal_reflux_disease_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -