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[Functional dyspepsia, gastric emptying of solids, and Helicobacter pylori infection].
Rev Esp Enferm Dig 1994; 85(5):325-30RE

Abstract

The origin of functional dyspepsia (FD) is unknown, however, abnormal gastric emptying and infection by H. pylori have been suggested as possible causes.

OBJECTIVE

The aim of this study was to test the hypothesis that infection by H. pylori could be related to alterations in gastric emptying of solids and play a role in the pathophysiology of dyspepsia.

METHODS

Studies were performed on 12 controls: 6 males, 6 females, age 40 +/- 13, and on 45 FD patients: 15 males and 30 females, age 43.5 +/- 12. Clinical criteria for FD diagnosis were post-prandial epigastric pain, nausea, vomiting or epigastric bloating, with normal blood test, upper endoscopy and abdominal ultrasound. Diagnosis of H. pylori infection was either by growth positive on culture of antral biopsy or by all of the following: on Gram stain, urease test positive and visualization of microorganisms in the antral biopsy. Gastric emptying of solids was studied with a radio-nuclide technique. Patients were prospectively classified in 4 groups according to the main symptom: reflux-like, ulcer-like, dysmotility, and non-specific.

RESULTS

H. pylori infection was observed in 21/32 (66%) FD patients. No significant differences in the gastric emptying of solids between the control group and patients with FD (tl/2 80 +/- 17 minutes vs 75 +/- 16 min). The presence of H. pylori infection did not influence gastric emptying rates (78 +/- 16 minutes in infected patients vs 73 +/- 15 min in non infected patients). Gastric emptying times were similar among the four subgroups of FD patients.

CONCLUSIONS

No significant differences in gastric emptying of solids were found in H. pylori infected persons as compared with the controls. These findings suggest that H. pylori infection and/or changes in gastric emptying of solids do not play a role in the pathophysiology of FD.

Authors+Show Affiliations

Servicio de Patología Digestiva, Hospital de le Universidad Autónoma, Barcelona.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

8049101

Citation

Monés Xiol, J, et al. "[Functional Dyspepsia, Gastric Emptying of Solids, and Helicobacter Pylori Infection]." Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, vol. 85, no. 5, 1994, pp. 325-30.
Monés Xiol J, Sainz Sáenz-Torre S, Carrió Gasset I, et al. [Functional dyspepsia, gastric emptying of solids, and Helicobacter pylori infection]. Rev Esp Enferm Dig. 1994;85(5):325-30.
Monés Xiol, J., Sainz Sáenz-Torre, S., Carrió Gasset, I., Berná Roqueta, L., Sancho Poch, F. J., & Vilardell Viñas, F. (1994). [Functional dyspepsia, gastric emptying of solids, and Helicobacter pylori infection]. Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, 85(5), pp. 325-30.
Monés Xiol J, et al. [Functional Dyspepsia, Gastric Emptying of Solids, and Helicobacter Pylori Infection]. Rev Esp Enferm Dig. 1994;85(5):325-30. PubMed PMID: 8049101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Functional dyspepsia, gastric emptying of solids, and Helicobacter pylori infection]. AU - Monés Xiol,J, AU - Sainz Sáenz-Torre,S, AU - Carrió Gasset,I, AU - Berná Roqueta,L, AU - Sancho Poch,F J, AU - Vilardell Viñas,F, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 325 EP - 30 JF - Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva JO - Rev Esp Enferm Dig VL - 85 IS - 5 N2 - UNLABELLED: The origin of functional dyspepsia (FD) is unknown, however, abnormal gastric emptying and infection by H. pylori have been suggested as possible causes. OBJECTIVE: The aim of this study was to test the hypothesis that infection by H. pylori could be related to alterations in gastric emptying of solids and play a role in the pathophysiology of dyspepsia. METHODS: Studies were performed on 12 controls: 6 males, 6 females, age 40 +/- 13, and on 45 FD patients: 15 males and 30 females, age 43.5 +/- 12. Clinical criteria for FD diagnosis were post-prandial epigastric pain, nausea, vomiting or epigastric bloating, with normal blood test, upper endoscopy and abdominal ultrasound. Diagnosis of H. pylori infection was either by growth positive on culture of antral biopsy or by all of the following: on Gram stain, urease test positive and visualization of microorganisms in the antral biopsy. Gastric emptying of solids was studied with a radio-nuclide technique. Patients were prospectively classified in 4 groups according to the main symptom: reflux-like, ulcer-like, dysmotility, and non-specific. RESULTS: H. pylori infection was observed in 21/32 (66%) FD patients. No significant differences in the gastric emptying of solids between the control group and patients with FD (tl/2 80 +/- 17 minutes vs 75 +/- 16 min). The presence of H. pylori infection did not influence gastric emptying rates (78 +/- 16 minutes in infected patients vs 73 +/- 15 min in non infected patients). Gastric emptying times were similar among the four subgroups of FD patients. CONCLUSIONS: No significant differences in gastric emptying of solids were found in H. pylori infected persons as compared with the controls. These findings suggest that H. pylori infection and/or changes in gastric emptying of solids do not play a role in the pathophysiology of FD. SN - 1130-0108 UR - https://www.unboundmedicine.com/medline/citation/8049101/[Functional_dyspepsia_gastric_emptying_of_solids_and_Helicobacter_pylori_infection]_ L2 - http://www.diseaseinfosearch.org/result/2394 DB - PRIME DP - Unbound Medicine ER -