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Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits.
Dermatology. 1994; 189 Suppl 1:111-4.D

Abstract

We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. Immunofluorescence tests showed intercellular IgA-kappa deposits in the upper portion of the lesional epidermis and circulating IgA-kappa anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-kappa paraprotein produced by myeloma cells.

Authors+Show Affiliations

Department of Dermatology, Kanazawa University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8049547

Citation

Takata, M, et al. "Subcorneal Pustular Dermatosis Associated With IgA Myeloma and Intraepidermal IgA Deposits." Dermatology (Basel, Switzerland), vol. 189 Suppl 1, 1994, pp. 111-4.
Takata M, Inaoki M, Shodo M, et al. Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits. Dermatology (Basel). 1994;189 Suppl 1:111-4.
Takata, M., Inaoki, M., Shodo, M., Hirone, T., & Kaya, H. (1994). Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits. Dermatology (Basel, Switzerland), 189 Suppl 1, 111-4.
Takata M, et al. Subcorneal Pustular Dermatosis Associated With IgA Myeloma and Intraepidermal IgA Deposits. Dermatology (Basel). 1994;189 Suppl 1:111-4. PubMed PMID: 8049547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits. AU - Takata,M, AU - Inaoki,M, AU - Shodo,M, AU - Hirone,T, AU - Kaya,H, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 111 EP - 4 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 189 Suppl 1 N2 - We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. Immunofluorescence tests showed intercellular IgA-kappa deposits in the upper portion of the lesional epidermis and circulating IgA-kappa anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-kappa paraprotein produced by myeloma cells. SN - 1018-8665 UR - https://www.unboundmedicine.com/medline/citation/8049547/Subcorneal_pustular_dermatosis_associated_with_IgA_myeloma_and_intraepidermal_IgA_deposits_ L2 - https://www.karger.com?DOI=10.1159/000246947 DB - PRIME DP - Unbound Medicine ER -