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Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs.
J Toxicol Environ Health. 1994 Aug; 42(4):435-42.JT

Abstract

Airway hyperresponsiveness can be induced by several stimuli including antigen and ozone, both of which may be present in the air of polluted cities. Though the effect of ozone on the bronchoconstrictor response to antigen has been well described, the combined effect of these stimuli on airway hyperresponsiveness has not yet been studied. Sensitized guinea pigs with or without ozone exposure for 1 h at 3 ppm, 18 h prior to study, were challenged with a dose-response curve to histamine (0.01-1.8 micrograms/kg, iv) followed by an antigen challenge (ovalbumin, 50 micrograms/kg, iv), and then by a second histamine dose-response curve 1 h later. Airway responses were measured as the increase in pulmonary insufflation pressure. In sensitized guinea pigs, the histamine ED50 significantly decreased after antigen challenge, demonstrating the development of airway hyperresponsiveness. Sensitized guinea pigs exposed to ozone showed airway hyperresponsiveness to histamine when compared with nonexposed animals, and such hyperresponsiveness was further enhanced after antigen challenge. We conclude that in this guinea pig model of acute allergic bronchoconstriction both antigen challenge and ozone induce airway hyperresponsiveness, while ozone exposure does not modify the development of antigen-induced hyperresponsiveness.

Authors+Show Affiliations

Unidad de Investigación Instituto Nacional de Enfermedades Respiratorias, SSA, Mexico DF, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8051717

Citation

Vargas, M H., et al. "Effect of Ozone Exposure On Antigen-induced Airway Hyperresponsiveness in Guinea Pigs." Journal of Toxicology and Environmental Health, vol. 42, no. 4, 1994, pp. 435-42.
Vargas MH, Segura P, Campos MG, et al. Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs. J Toxicol Environ Health. 1994;42(4):435-42.
Vargas, M. H., Segura, P., Campos, M. G., Hong, E., & Montaño, L. M. (1994). Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs. Journal of Toxicology and Environmental Health, 42(4), 435-42.
Vargas MH, et al. Effect of Ozone Exposure On Antigen-induced Airway Hyperresponsiveness in Guinea Pigs. J Toxicol Environ Health. 1994;42(4):435-42. PubMed PMID: 8051717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs. AU - Vargas,M H, AU - Segura,P, AU - Campos,M G, AU - Hong,E, AU - Montaño,L M, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 435 EP - 42 JF - Journal of toxicology and environmental health JO - J Toxicol Environ Health VL - 42 IS - 4 N2 - Airway hyperresponsiveness can be induced by several stimuli including antigen and ozone, both of which may be present in the air of polluted cities. Though the effect of ozone on the bronchoconstrictor response to antigen has been well described, the combined effect of these stimuli on airway hyperresponsiveness has not yet been studied. Sensitized guinea pigs with or without ozone exposure for 1 h at 3 ppm, 18 h prior to study, were challenged with a dose-response curve to histamine (0.01-1.8 micrograms/kg, iv) followed by an antigen challenge (ovalbumin, 50 micrograms/kg, iv), and then by a second histamine dose-response curve 1 h later. Airway responses were measured as the increase in pulmonary insufflation pressure. In sensitized guinea pigs, the histamine ED50 significantly decreased after antigen challenge, demonstrating the development of airway hyperresponsiveness. Sensitized guinea pigs exposed to ozone showed airway hyperresponsiveness to histamine when compared with nonexposed animals, and such hyperresponsiveness was further enhanced after antigen challenge. We conclude that in this guinea pig model of acute allergic bronchoconstriction both antigen challenge and ozone induce airway hyperresponsiveness, while ozone exposure does not modify the development of antigen-induced hyperresponsiveness. SN - 0098-4108 UR - https://www.unboundmedicine.com/medline/citation/8051717/Effect_of_ozone_exposure_on_antigen_induced_airway_hyperresponsiveness_in_guinea_pigs_ L2 - https://medlineplus.gov/ozone.html DB - PRIME DP - Unbound Medicine ER -