Tags

Type your tag names separated by a space and hit enter

Haemodynamic changes in portal hypertension: new insights in the pathogenesis and clinical implications.
Acta Gastroenterol Belg. 1994 Mar-Apr; 57(2):194-205.AG

Abstract

In man and experimental animals, portal hypertension with portal-venous collaterals, is associated with a hyperdynamic circulation, caused by peripheral vasodilatation, mainly in the splanchnic bed. This peripheral vasodilatation is clinically important, since it is thought to be responsible for the pathogenesis of complications of portal hypertension such as ascites, the hepatorenal syndrome and portal hypertensive gastropathy and colopathy. Many cirrhotic patients may not die primarily because of their hepatic dysfunction, but rather because of the consequences of the circulatory abnormalities which are secondary to the liver disease. Circulating hormonal vasodilators from intestinal origin such as glucagon, insufficiently cleared by the liver, are only partly responsible for these changes. Recent experimental data point to a role for an increased production of the locally acting potent vasodilator nitric oxide in the vascular wall, in the pathogenesis of the hyperdynamic circulation. Furthermore, nitric oxide seems to play an important role in the development of portal-venous collaterals. Modulation of the nitric oxide production might offer therapeutic options for the treatment of portal hypertension and its complications.

Authors+Show Affiliations

Michielsen PP
Division of Gastroenterology, Faculty of Medicine, University of Antwerp (U.I.A.), Belgium.
Pelckmans PA
No affiliation info available

MeSH

AscitesHemodynamicsHepatorenal SyndromeHumansHypertension, PortalLiver CirrhosisNitric OxideSplanchnic CirculationVasodilation

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8053307

Citation

Michielsen, P P., and P A. Pelckmans. "Haemodynamic Changes in Portal Hypertension: New Insights in the Pathogenesis and Clinical Implications." Acta Gastro-enterologica Belgica, vol. 57, no. 2, 1994, pp. 194-205.
Michielsen PP, Pelckmans PA. Haemodynamic changes in portal hypertension: new insights in the pathogenesis and clinical implications. Acta Gastroenterol Belg. 1994;57(2):194-205.
Michielsen, P. P., & Pelckmans, P. A. (1994). Haemodynamic changes in portal hypertension: new insights in the pathogenesis and clinical implications. Acta Gastro-enterologica Belgica, 57(2), 194-205.
Michielsen PP, Pelckmans PA. Haemodynamic Changes in Portal Hypertension: New Insights in the Pathogenesis and Clinical Implications. Acta Gastroenterol Belg. 1994 Mar-Apr;57(2):194-205. PubMed PMID: 8053307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemodynamic changes in portal hypertension: new insights in the pathogenesis and clinical implications. AU - Michielsen,P P, AU - Pelckmans,P A, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 194 EP - 205 JF - Acta gastro-enterologica Belgica JO - Acta Gastroenterol Belg VL - 57 IS - 2 N2 - In man and experimental animals, portal hypertension with portal-venous collaterals, is associated with a hyperdynamic circulation, caused by peripheral vasodilatation, mainly in the splanchnic bed. This peripheral vasodilatation is clinically important, since it is thought to be responsible for the pathogenesis of complications of portal hypertension such as ascites, the hepatorenal syndrome and portal hypertensive gastropathy and colopathy. Many cirrhotic patients may not die primarily because of their hepatic dysfunction, but rather because of the consequences of the circulatory abnormalities which are secondary to the liver disease. Circulating hormonal vasodilators from intestinal origin such as glucagon, insufficiently cleared by the liver, are only partly responsible for these changes. Recent experimental data point to a role for an increased production of the locally acting potent vasodilator nitric oxide in the vascular wall, in the pathogenesis of the hyperdynamic circulation. Furthermore, nitric oxide seems to play an important role in the development of portal-venous collaterals. Modulation of the nitric oxide production might offer therapeutic options for the treatment of portal hypertension and its complications. SN - 1784-3227 UR - https://www.unboundmedicine.com/medline/citation/8053307/Haemodynamic_changes_in_portal_hypertension:_new_insights_in_the_pathogenesis_and_clinical_implications_ L2 - http://www.diseaseinfosearch.org/result/5881 DB - PRIME DP - Unbound Medicine ER -