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Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV.
J Virol. 1994 Sep; 68(9):6069-73.JV

Abstract

During cultivation of the Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) line Akata, it was noted that EBV DNA is lost from some of the cells. Isolation of EBV-positive and EBV-negative clones with the same origin made it possible to examine the effects of EBV in BL cells. The results indicate that malignant phenotypes of BL, such as growth in low serum, anchorage-independent growth in soft agar, and tumorigenicity in nude mice, are dependent on the presence of EBV genomes and underline the oncogenic function of EBV in human cancer.

Authors+Show Affiliations

Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8057484

Citation

Shimizu, N, et al. "Isolation of Epstein-Barr Virus (EBV)-negative Cell Clones From the EBV-positive Burkitt's Lymphoma (BL) Line Akata: Malignant Phenotypes of BL Cells Are Dependent On EBV." Journal of Virology, vol. 68, no. 9, 1994, pp. 6069-73.
Shimizu N, Tanabe-Tochikura A, Kuroiwa Y, et al. Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV. J Virol. 1994;68(9):6069-73.
Shimizu, N., Tanabe-Tochikura, A., Kuroiwa, Y., & Takada, K. (1994). Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV. Journal of Virology, 68(9), 6069-73.
Shimizu N, et al. Isolation of Epstein-Barr Virus (EBV)-negative Cell Clones From the EBV-positive Burkitt's Lymphoma (BL) Line Akata: Malignant Phenotypes of BL Cells Are Dependent On EBV. J Virol. 1994;68(9):6069-73. PubMed PMID: 8057484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV. AU - Shimizu,N, AU - Tanabe-Tochikura,A, AU - Kuroiwa,Y, AU - Takada,K, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 6069 EP - 73 JF - Journal of virology JO - J. Virol. VL - 68 IS - 9 N2 - During cultivation of the Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) line Akata, it was noted that EBV DNA is lost from some of the cells. Isolation of EBV-positive and EBV-negative clones with the same origin made it possible to examine the effects of EBV in BL cells. The results indicate that malignant phenotypes of BL, such as growth in low serum, anchorage-independent growth in soft agar, and tumorigenicity in nude mice, are dependent on the presence of EBV genomes and underline the oncogenic function of EBV in human cancer. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/8057484/Isolation_of_Epstein_Barr_virus__EBV__negative_cell_clones_from_the_EBV_positive_Burkitt's_lymphoma__BL__line_Akata:_malignant_phenotypes_of_BL_cells_are_dependent_on_EBV_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=8057484 DB - PRIME DP - Unbound Medicine ER -