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Biomedical applications of tunable diode laser spectrometry: correlation between breath carbon monoxide and low level blood carboxyhemoglobin saturation.
Ann Biomed Eng. 1994 Jan-Feb; 22(1):120-5.AB

Abstract

Tunable diode laser spectrometry was used to measure breath carbon monoxide (CO) concentrations in nonsmoking subjects. Corresponding blood carboxyhemoglobin (COHb) saturations between physiological levels and levels after 1 and 8 hours exposure to 9 ppm CO, the maximum permissible concentration in the air under federal regulations, were also determined. A good linear correlation between breath CO and blood COHb saturation for low levels representing ambient conditions was established, with a correlation coefficient better than 0.999 for the means and 0.945 for the individual data points. Similar studies on the other compounds of concern are also possible using tunable diode laser spectrometry, requiring only a breath sample and with no sample preparation. This technique will facilitate fast, noninvasive environmental health effect and biomedical studies.

Authors+Show Affiliations

Lee PS
Department of Automotive Safety and Health Research, General Motors NAO Research and Development Center, Warren, MI 48090.
Schreck RM
No affiliation info available
Hare BA
No affiliation info available
McGrath JJ
No affiliation info available

MeSH

Breath TestsCarbon MonoxideCarboxyhemoglobinEnvironmental MonitoringEvaluation Studies as TopicHumansLasersLinear ModelsMaximum Allowable ConcentrationSensitivity and SpecificitySpectrum Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8060021

Citation

Lee, P S., et al. "Biomedical Applications of Tunable Diode Laser Spectrometry: Correlation Between Breath Carbon Monoxide and Low Level Blood Carboxyhemoglobin Saturation." Annals of Biomedical Engineering, vol. 22, no. 1, 1994, pp. 120-5.
Lee PS, Schreck RM, Hare BA, et al. Biomedical applications of tunable diode laser spectrometry: correlation between breath carbon monoxide and low level blood carboxyhemoglobin saturation. Ann Biomed Eng. 1994;22(1):120-5.
Lee, P. S., Schreck, R. M., Hare, B. A., & McGrath, J. J. (1994). Biomedical applications of tunable diode laser spectrometry: correlation between breath carbon monoxide and low level blood carboxyhemoglobin saturation. Annals of Biomedical Engineering, 22(1), 120-5.
Lee PS, et al. Biomedical Applications of Tunable Diode Laser Spectrometry: Correlation Between Breath Carbon Monoxide and Low Level Blood Carboxyhemoglobin Saturation. Ann Biomed Eng. 1994 Jan-Feb;22(1):120-5. PubMed PMID: 8060021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomedical applications of tunable diode laser spectrometry: correlation between breath carbon monoxide and low level blood carboxyhemoglobin saturation. AU - Lee,P S, AU - Schreck,R M, AU - Hare,B A, AU - McGrath,J J, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 120 EP - 5 JF - Annals of biomedical engineering JO - Ann Biomed Eng VL - 22 IS - 1 N2 - Tunable diode laser spectrometry was used to measure breath carbon monoxide (CO) concentrations in nonsmoking subjects. Corresponding blood carboxyhemoglobin (COHb) saturations between physiological levels and levels after 1 and 8 hours exposure to 9 ppm CO, the maximum permissible concentration in the air under federal regulations, were also determined. A good linear correlation between breath CO and blood COHb saturation for low levels representing ambient conditions was established, with a correlation coefficient better than 0.999 for the means and 0.945 for the individual data points. Similar studies on the other compounds of concern are also possible using tunable diode laser spectrometry, requiring only a breath sample and with no sample preparation. This technique will facilitate fast, noninvasive environmental health effect and biomedical studies. SN - 0090-6964 UR - https://www.unboundmedicine.com/medline/citation/8060021/Biomedical_applications_of_tunable_diode_laser_spectrometry:_correlation_between_breath_carbon_monoxide_and_low_level_blood_carboxyhemoglobin_saturation_ DB - PRIME DP - Unbound Medicine ER -