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[Neonatal cardiac failure secondary to hypocalcemia caused by maternal vitamin D deficiency].
Arch Fr Pediatr 1993; 50(9):787-91AF

Abstract

BACKGROUND

Heart failure is a rare manifestation of neonatal hypocalcemia. This paper describes such a case resulting from maternal vitamin D deficiency.

CASE REPORT

A full-term boy, born in December after a normal pregnancy, was admitted at the age of 6 weeks because of dyspnea that appeared during suckling. Examination showed heart failure. Electrocardiogram showed that the corrected QT-interval was lengthened (0.54 s, normal < 0.45 s). Echocardiogram showed dilated, hypokinetic myocardiopathy. His serum calcium concentration was low (1.40 mmol/l) and phosphate was high (2.8 mmol/l); his alkaline phosphatase was 513 Ul/l. His blood PTH concentration was high (120 pg/ml) and his 25 (OH) D was low (5 ng/ml). The patient was given calcium (1 g/m2/day) and 1.25 (OH)2 D (2 micrograms/day orally). His serum calcium returned to normal within 4 days, and his cardiac abnormality was resolved within 3 months. His mother's blood 25 (OH) D concentration was very low (3 ng/ml), 6 weeks after birth.

CONCLUSION

Neonatal hypocalcemia appears to have been compounded in this case by a maternal vitamin D deficiency. Hence, all pregnant women at risk of deficiency should be given vitamin D.

Authors+Show Affiliations

Unité d'Endocrinologie, CNRS URA, Hôpital et Faculté Necker-Enfants Malades, Paris.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

8060210

Citation

Memmi, I, et al. "[Neonatal Cardiac Failure Secondary to Hypocalcemia Caused By Maternal Vitamin D Deficiency]." Archives Francaises De Pediatrie, vol. 50, no. 9, 1993, pp. 787-91.
Memmi I, Brauner R, Sidi D, et al. [Neonatal cardiac failure secondary to hypocalcemia caused by maternal vitamin D deficiency]. Arch Fr Pediatr. 1993;50(9):787-91.
Memmi, I., Brauner, R., Sidi, D., Sauvion, S., Souberbielle, J. C., & Garabedian, M. (1993). [Neonatal cardiac failure secondary to hypocalcemia caused by maternal vitamin D deficiency]. Archives Francaises De Pediatrie, 50(9), pp. 787-91.
Memmi I, et al. [Neonatal Cardiac Failure Secondary to Hypocalcemia Caused By Maternal Vitamin D Deficiency]. Arch Fr Pediatr. 1993;50(9):787-91. PubMed PMID: 8060210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neonatal cardiac failure secondary to hypocalcemia caused by maternal vitamin D deficiency]. AU - Memmi,I, AU - Brauner,R, AU - Sidi,D, AU - Sauvion,S, AU - Souberbielle,J C, AU - Garabedian,M, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 787 EP - 91 JF - Archives francaises de pediatrie JO - Arch. Fr. Pediatr. VL - 50 IS - 9 N2 - BACKGROUND: Heart failure is a rare manifestation of neonatal hypocalcemia. This paper describes such a case resulting from maternal vitamin D deficiency. CASE REPORT: A full-term boy, born in December after a normal pregnancy, was admitted at the age of 6 weeks because of dyspnea that appeared during suckling. Examination showed heart failure. Electrocardiogram showed that the corrected QT-interval was lengthened (0.54 s, normal < 0.45 s). Echocardiogram showed dilated, hypokinetic myocardiopathy. His serum calcium concentration was low (1.40 mmol/l) and phosphate was high (2.8 mmol/l); his alkaline phosphatase was 513 Ul/l. His blood PTH concentration was high (120 pg/ml) and his 25 (OH) D was low (5 ng/ml). The patient was given calcium (1 g/m2/day) and 1.25 (OH)2 D (2 micrograms/day orally). His serum calcium returned to normal within 4 days, and his cardiac abnormality was resolved within 3 months. His mother's blood 25 (OH) D concentration was very low (3 ng/ml), 6 weeks after birth. CONCLUSION: Neonatal hypocalcemia appears to have been compounded in this case by a maternal vitamin D deficiency. Hence, all pregnant women at risk of deficiency should be given vitamin D. SN - 0003-9764 UR - https://www.unboundmedicine.com/medline/citation/8060210/[Neonatal_cardiac_failure_secondary_to_hypocalcemia_caused_by_maternal_vitamin_D_deficiency]_ L2 - https://medlineplus.gov/healthproblemsinpregnancy.html DB - PRIME DP - Unbound Medicine ER -