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Clinical profile and pattern of infection in Ethiopian children with severe protein-energy malnutrition.
East Afr Med J. 1994 Apr; 71(4):264-7.EA

Abstract

The results of a prospective study on the clinical profile and pattern of infection in 90 Ethiopian children with severe protein-energy malnutrition (PEM) is presented. The study group consisted of 44(49%) with marasmus, 29(32%) with marasmic-kwashiorkor and 17(19%) with kwashiorkor. Their age ranged from 4 to 60 months and the median age at admission was 11.5, 15 and 20 months, respectively. Over 80% of the patients were infected and the lungs were the commonest sites. Bacterial pathogens, predominantly Gram negative enteric organisms, were isolated from 36% of blood and 37% of urine specimens. Tuberculosis and non-typhoidal salmonellae showed a higher tendency of causing disseminated disease. Rickets and overt vitamin A deficiency were seen in 37% and 17% of the patients, respectively. Septicaemia, gastroenteritis, pneumonia and disseminated tuberculosis accounted for an overall case fatality rate of 32%. Mortality was higher in children with total serum protein of 5gm% or less. The clinical profile and the pattern of infection varied from observations made elsewhere in developing countries which also showed discrepant results. More comprehensive and carefully designed work is proposed to elucidate the clinical and geographic heterogeneity of severe PEM.

Authors+Show Affiliations

Shimeles D
Department of Paediatrics and Child Health, Faculty of Medicine, Addis Ababa University, Ethiopia.
Lulseged S
No affiliation info available

MeSH

Age DistributionChild Nutrition DisordersChild, PreschoolDeveloping CountriesEthiopiaFemaleHumansInfantInfant MortalityInfant, NewbornInfectionsMalePopulation SurveillanceProspective StudiesProtein-Energy MalnutritionSeverity of Illness Index

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8062777

Citation

Shimeles, D, and S Lulseged. "Clinical Profile and Pattern of Infection in Ethiopian Children With Severe Protein-energy Malnutrition." East African Medical Journal, vol. 71, no. 4, 1994, pp. 264-7.
Shimeles D, Lulseged S. Clinical profile and pattern of infection in Ethiopian children with severe protein-energy malnutrition. East Afr Med J. 1994;71(4):264-7.
Shimeles, D., & Lulseged, S. (1994). Clinical profile and pattern of infection in Ethiopian children with severe protein-energy malnutrition. East African Medical Journal, 71(4), 264-7.
Shimeles D, Lulseged S. Clinical Profile and Pattern of Infection in Ethiopian Children With Severe Protein-energy Malnutrition. East Afr Med J. 1994;71(4):264-7. PubMed PMID: 8062777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical profile and pattern of infection in Ethiopian children with severe protein-energy malnutrition. AU - Shimeles,D, AU - Lulseged,S, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Child KW - Child Health KW - Child Mortality KW - Child Nutrition KW - Child Survival KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Eastern Africa KW - Ethiopia KW - Health KW - Infections KW - Length Of Life KW - Malnutrition KW - Measurement KW - Mortality KW - Nutrition KW - Nutrition Disorders KW - Population KW - Population Characteristics KW - Population Dynamics KW - Prevalence KW - Prospective Studies KW - Research Methodology KW - Research Report KW - Signs And Symptoms KW - Studies KW - Survivorship KW - Youth SP - 264 EP - 7 JF - East African medical journal JO - East Afr Med J VL - 71 IS - 4 N2 - The results of a prospective study on the clinical profile and pattern of infection in 90 Ethiopian children with severe protein-energy malnutrition (PEM) is presented. The study group consisted of 44(49%) with marasmus, 29(32%) with marasmic-kwashiorkor and 17(19%) with kwashiorkor. Their age ranged from 4 to 60 months and the median age at admission was 11.5, 15 and 20 months, respectively. Over 80% of the patients were infected and the lungs were the commonest sites. Bacterial pathogens, predominantly Gram negative enteric organisms, were isolated from 36% of blood and 37% of urine specimens. Tuberculosis and non-typhoidal salmonellae showed a higher tendency of causing disseminated disease. Rickets and overt vitamin A deficiency were seen in 37% and 17% of the patients, respectively. Septicaemia, gastroenteritis, pneumonia and disseminated tuberculosis accounted for an overall case fatality rate of 32%. Mortality was higher in children with total serum protein of 5gm% or less. The clinical profile and the pattern of infection varied from observations made elsewhere in developing countries which also showed discrepant results. More comprehensive and carefully designed work is proposed to elucidate the clinical and geographic heterogeneity of severe PEM. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/8062777/Clinical_profile_and_pattern_of_infection_in_Ethiopian_children_with_severe_protein_energy_malnutrition_ L2 - https://medlineplus.gov/childnutrition.html DB - PRIME DP - Unbound Medicine ER -