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Time course of decline of radiolabeled acetylcholine formed following intracerebroventricular administration of tritiated choline: effects of oxotremorine and scopolamine.
Neurochem Res. 1994 Apr; 19(4):407-13.NR

Abstract

Rats were injected intracerebroventricularly with 5 microCi of [methyl-3H]choline. The time course of decline of the radiolabeled acetylcholine (ACh) formed was estimated in the ipsilateral cerebral cortex and striatum. The [3H]ACh levels declined biphasically from the cerebral tissue. The initial decline proceeded rapidly, after which labeled ACh declined more slowly. Scopolamine (1 mg/kg, i.v.) caused a significant increase in the rate of [3H]ACh disappearance, which can be interpreted as an enhancement of ACh release. By contrast, oxotremorine (0.8 mg/kg, i.v.) markedly reduced the [3H]ACh disappearance. The results show that drug-induced changes in cholinergic neuronal activities can be estimated from the disappearance of radioactive ACh after labeling the endogenous transmitter through intracerebroventricular administration of labeled choline.

Authors+Show Affiliations

Laboratoire de Pharmacodynamie, Faculté de Pharmacie, Dijon, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8065497

Citation

Bertrand, N, et al. "Time Course of Decline of Radiolabeled Acetylcholine Formed Following Intracerebroventricular Administration of Tritiated Choline: Effects of Oxotremorine and Scopolamine." Neurochemical Research, vol. 19, no. 4, 1994, pp. 407-13.
Bertrand N, Bralet J, Beley A. Time course of decline of radiolabeled acetylcholine formed following intracerebroventricular administration of tritiated choline: effects of oxotremorine and scopolamine. Neurochem Res. 1994;19(4):407-13.
Bertrand, N., Bralet, J., & Beley, A. (1994). Time course of decline of radiolabeled acetylcholine formed following intracerebroventricular administration of tritiated choline: effects of oxotremorine and scopolamine. Neurochemical Research, 19(4), 407-13.
Bertrand N, Bralet J, Beley A. Time Course of Decline of Radiolabeled Acetylcholine Formed Following Intracerebroventricular Administration of Tritiated Choline: Effects of Oxotremorine and Scopolamine. Neurochem Res. 1994;19(4):407-13. PubMed PMID: 8065497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time course of decline of radiolabeled acetylcholine formed following intracerebroventricular administration of tritiated choline: effects of oxotremorine and scopolamine. AU - Bertrand,N, AU - Bralet,J, AU - Beley,A, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 407 EP - 13 JF - Neurochemical research JO - Neurochem Res VL - 19 IS - 4 N2 - Rats were injected intracerebroventricularly with 5 microCi of [methyl-3H]choline. The time course of decline of the radiolabeled acetylcholine (ACh) formed was estimated in the ipsilateral cerebral cortex and striatum. The [3H]ACh levels declined biphasically from the cerebral tissue. The initial decline proceeded rapidly, after which labeled ACh declined more slowly. Scopolamine (1 mg/kg, i.v.) caused a significant increase in the rate of [3H]ACh disappearance, which can be interpreted as an enhancement of ACh release. By contrast, oxotremorine (0.8 mg/kg, i.v.) markedly reduced the [3H]ACh disappearance. The results show that drug-induced changes in cholinergic neuronal activities can be estimated from the disappearance of radioactive ACh after labeling the endogenous transmitter through intracerebroventricular administration of labeled choline. SN - 0364-3190 UR - https://www.unboundmedicine.com/medline/citation/8065497/Time_course_of_decline_of_radiolabeled_acetylcholine_formed_following_intracerebroventricular_administration_of_tritiated_choline:_effects_of_oxotremorine_and_scopolamine_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:8065497 DB - PRIME DP - Unbound Medicine ER -