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Potentiating effect of inhaled acetaldehyde on bronchial responsiveness to methacholine in asthmatic subjects.
Thorax. 1994 Jul; 49(7):644-8.T

Abstract

BACKGROUND

It has recently been reported that acetaldehyde induces bronchoconstriction indirectly via histamine release. However, no study has been performed to assess whether acetaldehyde worsens bronchial responsiveness in asthmatic subjects so this hypothesis was tested.

METHODS

Methacholine provocation was performed on three occasions: (1) after pretreatment with oral placebo and inhaled saline (P-S day), (2) after placebo and inhaled acetaldehyde (P-A day), and (3) after a potent histamine H1 receptor antagonist terfenadine and acetaldehyde (T-A day) in a double blind, randomised, crossover fashion. Nine asthmatic subjects inhaled 0.8 mg/ml acetaldehyde or saline for four minutes. After each inhalation a methacholine provocation test was performed.

RESULTS

Methacholine concentrations producing a 20% fall in FEV1 (PC20-MCh) on the P-A day (0.48 mg/ml, 95% CI 0.21 to 1.08) and T-A day (0.41 mg/ml, 95% CI 0.22 to 0.77) were lower than those on the P-S day (0.85 mg/ml, 95% CI 0.47 to 1.54). There was no change in the PC20-MCh between the P-A and T-A days. A correlation was observed between the logarithmic values of PC20-MCh (log PC20-MCh) on the P-S day and the potentiating effect of acetaldehyde on the methacholine responsiveness [(log PC20-MCh on P-A day)-(log PC20-MCh on P-S day)] (rho = 0.82).

CONCLUSIONS

Acetaldehyde induces bronchial hyperresponsiveness in patients with asthma by mechanisms other than histamine release.

Authors+Show Affiliations

Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8066557

Citation

Myou, S, et al. "Potentiating Effect of Inhaled Acetaldehyde On Bronchial Responsiveness to Methacholine in Asthmatic Subjects." Thorax, vol. 49, no. 7, 1994, pp. 644-8.
Myou S, Fujimura M, Nishi K, et al. Potentiating effect of inhaled acetaldehyde on bronchial responsiveness to methacholine in asthmatic subjects. Thorax. 1994;49(7):644-8.
Myou, S., Fujimura, M., Nishi, K., Matsuda, M., Ohka, T., & Matsuda, T. (1994). Potentiating effect of inhaled acetaldehyde on bronchial responsiveness to methacholine in asthmatic subjects. Thorax, 49(7), 644-8.
Myou S, et al. Potentiating Effect of Inhaled Acetaldehyde On Bronchial Responsiveness to Methacholine in Asthmatic Subjects. Thorax. 1994;49(7):644-8. PubMed PMID: 8066557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potentiating effect of inhaled acetaldehyde on bronchial responsiveness to methacholine in asthmatic subjects. AU - Myou,S, AU - Fujimura,M, AU - Nishi,K, AU - Matsuda,M, AU - Ohka,T, AU - Matsuda,T, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 644 EP - 8 JF - Thorax JO - Thorax VL - 49 IS - 7 N2 - BACKGROUND: It has recently been reported that acetaldehyde induces bronchoconstriction indirectly via histamine release. However, no study has been performed to assess whether acetaldehyde worsens bronchial responsiveness in asthmatic subjects so this hypothesis was tested. METHODS: Methacholine provocation was performed on three occasions: (1) after pretreatment with oral placebo and inhaled saline (P-S day), (2) after placebo and inhaled acetaldehyde (P-A day), and (3) after a potent histamine H1 receptor antagonist terfenadine and acetaldehyde (T-A day) in a double blind, randomised, crossover fashion. Nine asthmatic subjects inhaled 0.8 mg/ml acetaldehyde or saline for four minutes. After each inhalation a methacholine provocation test was performed. RESULTS: Methacholine concentrations producing a 20% fall in FEV1 (PC20-MCh) on the P-A day (0.48 mg/ml, 95% CI 0.21 to 1.08) and T-A day (0.41 mg/ml, 95% CI 0.22 to 0.77) were lower than those on the P-S day (0.85 mg/ml, 95% CI 0.47 to 1.54). There was no change in the PC20-MCh between the P-A and T-A days. A correlation was observed between the logarithmic values of PC20-MCh (log PC20-MCh) on the P-S day and the potentiating effect of acetaldehyde on the methacholine responsiveness [(log PC20-MCh on P-A day)-(log PC20-MCh on P-S day)] (rho = 0.82). CONCLUSIONS: Acetaldehyde induces bronchial hyperresponsiveness in patients with asthma by mechanisms other than histamine release. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/8066557/Potentiating_effect_of_inhaled_acetaldehyde_on_bronchial_responsiveness_to_methacholine_in_asthmatic_subjects_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=8066557 DB - PRIME DP - Unbound Medicine ER -