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The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. III. The effect on primary humoral response to sheep erythrocytes.
Acta Pol Pharm 1993; 50(6):491-6AP

Abstract

Tołpa Peat Preparation (TPP) was administered to mice in daily doses of 1, 10 and 50 mg.kg-1 for 3, 5, 7, 9 or 12 consecutive weeks. After each of the above mentioned periods the primary response to sheep erythrocytes (SRBC) was examined by determination of the percentage of splenocytes forming E rosettes, the number of splenocytes producing anti-SRBC haemolysins of 19S and 7S type, and the level of serum haemagglutinins to SRBC (19S + 7S and 7S types). The effect of enhanced humoral response by TPP was observed in mice immunized with SRBC. This effect depended, first of all on TPP does but also on the duration of time TPP administration. The stimulating effect on the humoral response occurred after the daily dose of 1 mg.kg-1 during 12 weeks. On the other hand, the daily doses of 10 or 50 times higher enhanced the humoral response only during the first 5-7 weeks of TPP administration. Longer administration of TPP in these doses caused disappearance of this effect or reduction of the response to SRBC.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Agriculture University, Wrocław, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8067261

Citation

Obmińska-Domoradzka, B, et al. "The Influence of Long-term Administration of Tołpa Peat Preparation On Immune Reactivity in Mice. III. the Effect On Primary Humoral Response to Sheep Erythrocytes." Acta Poloniae Pharmaceutica, vol. 50, no. 6, 1993, pp. 491-6.
Obmińska-Domoradzka B, Debowy J, Garbuliński T. The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. III. The effect on primary humoral response to sheep erythrocytes. Acta Pol Pharm. 1993;50(6):491-6.
Obmińska-Domoradzka, B., Debowy, J., & Garbuliński, T. (1993). The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. III. The effect on primary humoral response to sheep erythrocytes. Acta Poloniae Pharmaceutica, 50(6), pp. 491-6.
Obmińska-Domoradzka B, Debowy J, Garbuliński T. The Influence of Long-term Administration of Tołpa Peat Preparation On Immune Reactivity in Mice. III. the Effect On Primary Humoral Response to Sheep Erythrocytes. Acta Pol Pharm. 1993;50(6):491-6. PubMed PMID: 8067261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. III. The effect on primary humoral response to sheep erythrocytes. AU - Obmińska-Domoradzka,B, AU - Debowy,J, AU - Garbuliński,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 491 EP - 6 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 6 N2 - Tołpa Peat Preparation (TPP) was administered to mice in daily doses of 1, 10 and 50 mg.kg-1 for 3, 5, 7, 9 or 12 consecutive weeks. After each of the above mentioned periods the primary response to sheep erythrocytes (SRBC) was examined by determination of the percentage of splenocytes forming E rosettes, the number of splenocytes producing anti-SRBC haemolysins of 19S and 7S type, and the level of serum haemagglutinins to SRBC (19S + 7S and 7S types). The effect of enhanced humoral response by TPP was observed in mice immunized with SRBC. This effect depended, first of all on TPP does but also on the duration of time TPP administration. The stimulating effect on the humoral response occurred after the daily dose of 1 mg.kg-1 during 12 weeks. On the other hand, the daily doses of 10 or 50 times higher enhanced the humoral response only during the first 5-7 weeks of TPP administration. Longer administration of TPP in these doses caused disappearance of this effect or reduction of the response to SRBC. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/8067261/The_influence_of_long_term_administration_of_Tołpa_Peat_Preparation_on_immune_reactivity_in_mice__III__The_effect_on_primary_humoral_response_to_sheep_erythrocytes_ DB - PRIME DP - Unbound Medicine ER -