Tags

Type your tag names separated by a space and hit enter

The dose-dependent effect of Tołpa Peat Preparation on the humoral response of mice immunized with sheep erythrocytes.
Acta Pol Pharm 1993; 50(6):497-500AP

Abstract

The Balb/c strain mice were immunized by single intraperitoneal administration of 0.2 cm3 of 10% sheep erythrocyte suspension (SRBC). Tołpa Peat Preparation (TPP) used in the study was a peat-derived substance obtained in prof. St. Tołpa's laboratory. It was given to mice intraperitoneally, 4 times at 24-hour intervals. The first dose was administered 2 hours before immunization. Testing was performed with the following doses: 0.5, 2.5, 5, 10, 25, 50, 100 and 250 mg/kg. The determinations comprised the number of spleen cells producing anti-SRBC haemolysins, the level of serum haemagglutinins to SRBC (19S+7S and 7S types) and the percentage of splenocytes forming spontaneous E-rosettes. It was found that the effect of TPP on these immunologic parameters of the mice immunized with SRBC was dose-dependent. The effect potentiating the humoral response occurred for the doses of 0.5-10 mg/kg. The doses of 25 and 50 mg/kg did not affect the immunologic response to SRBC, while the doses of 100 and 250 mg/kg had a suppressive effect. The impact of TPP on the percentage of splenocytes forming E-rosettes was also dose-dependent, but in this case stimulating activity was observed for the doses of 2.5-25 mg/kg.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Agriculture University, Wrocław, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8067262

Citation

Obmińska-Domoradzka, B, et al. "The Dose-dependent Effect of Tołpa Peat Preparation On the Humoral Response of Mice Immunized With Sheep Erythrocytes." Acta Poloniae Pharmaceutica, vol. 50, no. 6, 1993, pp. 497-500.
Obmińska-Domoradzka B, Switała M, Debowy J, et al. The dose-dependent effect of Tołpa Peat Preparation on the humoral response of mice immunized with sheep erythrocytes. Acta Pol Pharm. 1993;50(6):497-500.
Obmińska-Domoradzka, B., Switała, M., Debowy, J., & Garbulński, T. (1993). The dose-dependent effect of Tołpa Peat Preparation on the humoral response of mice immunized with sheep erythrocytes. Acta Poloniae Pharmaceutica, 50(6), pp. 497-500.
Obmińska-Domoradzka B, et al. The Dose-dependent Effect of Tołpa Peat Preparation On the Humoral Response of Mice Immunized With Sheep Erythrocytes. Acta Pol Pharm. 1993;50(6):497-500. PubMed PMID: 8067262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dose-dependent effect of Tołpa Peat Preparation on the humoral response of mice immunized with sheep erythrocytes. AU - Obmińska-Domoradzka,B, AU - Switała,M, AU - Debowy,J, AU - Garbulński,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 497 EP - 500 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 6 N2 - The Balb/c strain mice were immunized by single intraperitoneal administration of 0.2 cm3 of 10% sheep erythrocyte suspension (SRBC). Tołpa Peat Preparation (TPP) used in the study was a peat-derived substance obtained in prof. St. Tołpa's laboratory. It was given to mice intraperitoneally, 4 times at 24-hour intervals. The first dose was administered 2 hours before immunization. Testing was performed with the following doses: 0.5, 2.5, 5, 10, 25, 50, 100 and 250 mg/kg. The determinations comprised the number of spleen cells producing anti-SRBC haemolysins, the level of serum haemagglutinins to SRBC (19S+7S and 7S types) and the percentage of splenocytes forming spontaneous E-rosettes. It was found that the effect of TPP on these immunologic parameters of the mice immunized with SRBC was dose-dependent. The effect potentiating the humoral response occurred for the doses of 0.5-10 mg/kg. The doses of 25 and 50 mg/kg did not affect the immunologic response to SRBC, while the doses of 100 and 250 mg/kg had a suppressive effect. The impact of TPP on the percentage of splenocytes forming E-rosettes was also dose-dependent, but in this case stimulating activity was observed for the doses of 2.5-25 mg/kg. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/8067262/The_dose_dependent_effect_of_Tołpa_Peat_Preparation_on_the_humoral_response_of_mice_immunized_with_sheep_erythrocytes_ DB - PRIME DP - Unbound Medicine ER -