Tags

Type your tag names separated by a space and hit enter

The relation of vasectomy to the risk of cancer.
Am J Epidemiol 1994; 140(5):431-8AJ

Abstract

We previously reported a strong positive association between vasectomy and the risk of prostatic cancer that arose in multiple comparisons made within data collected from 1976 to 1988 in an ongoing hospital-based surveillance study of many exposures and diseases. We have reassessed this association with data collected in the surveillance study during 1988-1992 from a new set of patients (355 cases of prostatic cancer and 2,048 controls with nonmalignant conditions). Because some studies have reported increased relative risks of lung cancer and testicular cancer in vasectomized men, we also used the surveillance database (4,126 men with various cancers, 7,027 men with nonmalignant conditions) to assess the relation of vasectomy to the risk of these and other cancers. In the newly collected data, the multivariate relative risk estimate for prostatic cancer in vasectomized men was 1.2 (95% confidence interval (CI) 0.6-2.7). For lung cancer and testicular cancer, the relative risk estimates were 1.3 (95% CI 0.8-2.1) and 0.8 (95% CI 0.4-1.9), respectively; for lung cancer occurring > or = 15 years after vasectomy, the relative risk estimate was 1.9 but it was not statistically significant (95% CI 0.7-5.0). For pancreatic cancer, the relative risk estimate was 1.8 (95% CI 1.0-3.1). For each of the other cancers considered--malignant melanoma, large bowel cancer, bladder cancer, kidney cancer, lymphoma, leukemia, and other cancers--the relative risk estimate was 1.3 or less and compatible with a value of 1.0. The present data provide little support for an association of vasectomy with the risk of prostatic cancer or other cancers. In addition, the data from two sets of cases of prostatic cancer and controls interviewed consecutively illustrate that increased relative risks detected in screening for statistically significant associations may tend to have an upward bias and to be lower in subsequent data.

Authors+Show Affiliations

Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, MA 02146.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8067335

Citation

Rosenberg, L, et al. "The Relation of Vasectomy to the Risk of Cancer." American Journal of Epidemiology, vol. 140, no. 5, 1994, pp. 431-8.
Rosenberg L, Palmer JR, Zauber AG, et al. The relation of vasectomy to the risk of cancer. Am J Epidemiol. 1994;140(5):431-8.
Rosenberg, L., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Strom, B. L., Harlap, S., & Shapiro, S. (1994). The relation of vasectomy to the risk of cancer. American Journal of Epidemiology, 140(5), pp. 431-8.
Rosenberg L, et al. The Relation of Vasectomy to the Risk of Cancer. Am J Epidemiol. 1994 Sep 1;140(5):431-8. PubMed PMID: 8067335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation of vasectomy to the risk of cancer. AU - Rosenberg,L, AU - Palmer,J R, AU - Zauber,A G, AU - Warshauer,M E, AU - Strom,B L, AU - Harlap,S, AU - Shapiro,S, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez KW - Americas KW - Bias KW - Biology KW - Cancer--men KW - Developed Countries KW - Diseases KW - Error Sources KW - Family Planning KW - Genital Effects, Male KW - Genitalia KW - Genitalia, Male KW - Male Sterilization KW - Measurement KW - Neoplasms KW - North America KW - Northern America KW - Physiology KW - Prostate KW - Pulmonary Effects KW - Risk Factors KW - Sterilization, Sexual KW - Technical Report KW - United States KW - Urogenital System KW - Vasectomy SP - 431 EP - 8 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 140 IS - 5 N2 - We previously reported a strong positive association between vasectomy and the risk of prostatic cancer that arose in multiple comparisons made within data collected from 1976 to 1988 in an ongoing hospital-based surveillance study of many exposures and diseases. We have reassessed this association with data collected in the surveillance study during 1988-1992 from a new set of patients (355 cases of prostatic cancer and 2,048 controls with nonmalignant conditions). Because some studies have reported increased relative risks of lung cancer and testicular cancer in vasectomized men, we also used the surveillance database (4,126 men with various cancers, 7,027 men with nonmalignant conditions) to assess the relation of vasectomy to the risk of these and other cancers. In the newly collected data, the multivariate relative risk estimate for prostatic cancer in vasectomized men was 1.2 (95% confidence interval (CI) 0.6-2.7). For lung cancer and testicular cancer, the relative risk estimates were 1.3 (95% CI 0.8-2.1) and 0.8 (95% CI 0.4-1.9), respectively; for lung cancer occurring > or = 15 years after vasectomy, the relative risk estimate was 1.9 but it was not statistically significant (95% CI 0.7-5.0). For pancreatic cancer, the relative risk estimate was 1.8 (95% CI 1.0-3.1). For each of the other cancers considered--malignant melanoma, large bowel cancer, bladder cancer, kidney cancer, lymphoma, leukemia, and other cancers--the relative risk estimate was 1.3 or less and compatible with a value of 1.0. The present data provide little support for an association of vasectomy with the risk of prostatic cancer or other cancers. In addition, the data from two sets of cases of prostatic cancer and controls interviewed consecutively illustrate that increased relative risks detected in screening for statistically significant associations may tend to have an upward bias and to be lower in subsequent data. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/8067335/The_relation_of_vasectomy_to_the_risk_of_cancer_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a117265 DB - PRIME DP - Unbound Medicine ER -