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Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan.
Anticancer Res. 1994 May-Jun; 14(3B):1389-92.AR

Abstract

In order to estimate the seroprevalence and explore multiple risk factors associated with Helicobacter pylori infection among residents in Taiwan, a total of 823 subjects randomly selected from one metropolitan precinct and three townships were studied. Serum samples were tested for IgG antibodies against H. pylori by enzyme-linked immunosorbent assay using commercial kits. The overall seropositive rate was 54.4% with no gender difference (53.7% for males and 55.2% for females). There was a significant geographical variation with the highest seropositive rate (63.4%) in rural area where aborigines live, and where the age-adjusted stomach cancer mortality is highest and the lowest (40.5%) in urban area where Hakkas live, and where the stomach cancer mortality is lowest. There was also an increasing seropositive rate with age from 27.1% for children younger than 10 years old to 72.3% for adults aged more than 40 years old. Age-specific seroprevalence in Taiwan is higher than that in United States, France, Finland and Australia, and lower than that in Algeria, Ivory Coast and India. No association with H. pylori seropositivity was observed for drinking water source, toilet type, family income and educational level after adjusting for age and area. A dose-response relation between H. pylori seropositivity and sibship size was found. Upon further analysis of seroprevalence for children aged 16 or younger, a positive association was observed for birth order and current number of children in family; there was also an inverse association for current number of adults in family. The early childhood transmission among siblings seems an important determinant of H. pylori seropositivity in Taiwan.

Authors+Show Affiliations

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8067711

Citation

Teh, B H., et al. "Seroprevalence and Associated Risk Factors of Helicobacter Pylori Infection in Taiwan." Anticancer Research, vol. 14, no. 3B, 1994, pp. 1389-92.
Teh BH, Lin JT, Pan WH, et al. Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan. Anticancer Res. 1994;14(3B):1389-92.
Teh, B. H., Lin, J. T., Pan, W. H., Lin, S. H., Wang, L. Y., Lee, T. K., & Chen, C. J. (1994). Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan. Anticancer Research, 14(3B), 1389-92.
Teh BH, et al. Seroprevalence and Associated Risk Factors of Helicobacter Pylori Infection in Taiwan. Anticancer Res. 1994 May-Jun;14(3B):1389-92. PubMed PMID: 8067711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan. AU - Teh,B H, AU - Lin,J T, AU - Pan,W H, AU - Lin,S H, AU - Wang,L Y, AU - Lee,T K, AU - Chen,C J, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 1389 EP - 92 JF - Anticancer research JO - Anticancer Res VL - 14 IS - 3B N2 - In order to estimate the seroprevalence and explore multiple risk factors associated with Helicobacter pylori infection among residents in Taiwan, a total of 823 subjects randomly selected from one metropolitan precinct and three townships were studied. Serum samples were tested for IgG antibodies against H. pylori by enzyme-linked immunosorbent assay using commercial kits. The overall seropositive rate was 54.4% with no gender difference (53.7% for males and 55.2% for females). There was a significant geographical variation with the highest seropositive rate (63.4%) in rural area where aborigines live, and where the age-adjusted stomach cancer mortality is highest and the lowest (40.5%) in urban area where Hakkas live, and where the stomach cancer mortality is lowest. There was also an increasing seropositive rate with age from 27.1% for children younger than 10 years old to 72.3% for adults aged more than 40 years old. Age-specific seroprevalence in Taiwan is higher than that in United States, France, Finland and Australia, and lower than that in Algeria, Ivory Coast and India. No association with H. pylori seropositivity was observed for drinking water source, toilet type, family income and educational level after adjusting for age and area. A dose-response relation between H. pylori seropositivity and sibship size was found. Upon further analysis of seroprevalence for children aged 16 or younger, a positive association was observed for birth order and current number of children in family; there was also an inverse association for current number of adults in family. The early childhood transmission among siblings seems an important determinant of H. pylori seropositivity in Taiwan. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/8067711/Seroprevalence_and_associated_risk_factors_of_Helicobacter_pylori_infection_in_Taiwan_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -