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Recreational exposure to sunlight and lack of information as risk factors for cutaneous malignant melanoma. Results of an European Organization for Research and Treatment of Cancer (EORTC) case-control study in Belgium, France and Germany. The EORTC Malignant Melanoma Cooperative Group.

Abstract

This study addressed the impact of exposure to ultraviolet radiation on the risk of cutaneous malignant melanoma (CMM), as well as the behavioral components at stake in its occurrence. We performed a one-to-one unmatched case-control study among subjects aged 20 years or more with naturally non-pigmented skin in Germany, France and Belgium. Four-hundred and twenty consecutive patients with CMM diagnosed from 1 January 1991 on were derived from hospital registries; 447 controls were chosen randomly in the same municipality as cases. Subjects unaware of the dangers of exaggerated exposure to sunlight display an estimated CMM risk of 3.72% (95% confidence interval 2.63-5.26). The number of holiday weeks spent annually in sunny resorts and sunbathing during the hot hours of the day are strong risk factors in the three countries, but not the number of years spent outdoors, as farmers or building workers. Multiple logistic adjustments on the host characteristics increases the CMM risk associated with recreational exposure to sunlight, as well as the adjustment on the unawareness of the dangers of exaggerated exposure to sunlight. Recreational exposure to sunlight and sunburn early in life seem capable of fostering the proliferation of pigmented lesions of the skin. Our data support the hypothesis that most CMM develop from pigmented lesions of the skin containing initiated melanocytes, and that the cell proliferation due to brutal, intermittent exposures to solar radiation amplifies the likelihood of a melanocyte entering into a malignant process.(

ABSTRACT

TRUNCATED AT 250 WORDS)

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  • Authors+Show Affiliations

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    Oeuvre Belge du Cancer, Brussels, Belgium.

    , , , , , , , ,

    Source

    Melanoma research 4:2 1994 Apr pg 79-85

    MeSH

    Adult
    Belgium
    Case-Control Studies
    Environmental Exposure
    Female
    France
    Germany
    Health Education
    Heliotherapy
    Humans
    Male
    Melanoma
    Melanosis
    Middle Aged
    Recreation
    Risk Factors
    Skin Neoplasms
    Skin Pigmentation
    Sunburn
    Sunlight

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8069100

    Citation

    Autier, P, et al. "Recreational Exposure to Sunlight and Lack of Information as Risk Factors for Cutaneous Malignant Melanoma. Results of an European Organization for Research and Treatment of Cancer (EORTC) Case-control Study in Belgium, France and Germany. the EORTC Malignant Melanoma Cooperative Group." Melanoma Research, vol. 4, no. 2, 1994, pp. 79-85.
    Autier P, Doré JF, Lejeune F, et al. Recreational exposure to sunlight and lack of information as risk factors for cutaneous malignant melanoma. Results of an European Organization for Research and Treatment of Cancer (EORTC) case-control study in Belgium, France and Germany. The EORTC Malignant Melanoma Cooperative Group. Melanoma Res. 1994;4(2):79-85.
    Autier, P., Doré, J. F., Lejeune, F., Koelmel, K. F., Geffeler, O., Hille, P., ... Joarlette, M. (1994). Recreational exposure to sunlight and lack of information as risk factors for cutaneous malignant melanoma. Results of an European Organization for Research and Treatment of Cancer (EORTC) case-control study in Belgium, France and Germany. The EORTC Malignant Melanoma Cooperative Group. Melanoma Research, 4(2), pp. 79-85.
    Autier P, et al. Recreational Exposure to Sunlight and Lack of Information as Risk Factors for Cutaneous Malignant Melanoma. Results of an European Organization for Research and Treatment of Cancer (EORTC) Case-control Study in Belgium, France and Germany. the EORTC Malignant Melanoma Cooperative Group. Melanoma Res. 1994;4(2):79-85. PubMed PMID: 8069100.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Recreational exposure to sunlight and lack of information as risk factors for cutaneous malignant melanoma. Results of an European Organization for Research and Treatment of Cancer (EORTC) case-control study in Belgium, France and Germany. The EORTC Malignant Melanoma Cooperative Group. A1 - Autier,P, AU - Doré,J F, AU - Lejeune,F, AU - Koelmel,K F, AU - Geffeler,O, AU - Hille,P, AU - Cesarini,J P, AU - Liénard,D, AU - Liabeuf,A, AU - Joarlette,M, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 79 EP - 85 JF - Melanoma research JO - Melanoma Res. VL - 4 IS - 2 N2 - This study addressed the impact of exposure to ultraviolet radiation on the risk of cutaneous malignant melanoma (CMM), as well as the behavioral components at stake in its occurrence. We performed a one-to-one unmatched case-control study among subjects aged 20 years or more with naturally non-pigmented skin in Germany, France and Belgium. Four-hundred and twenty consecutive patients with CMM diagnosed from 1 January 1991 on were derived from hospital registries; 447 controls were chosen randomly in the same municipality as cases. Subjects unaware of the dangers of exaggerated exposure to sunlight display an estimated CMM risk of 3.72% (95% confidence interval 2.63-5.26). The number of holiday weeks spent annually in sunny resorts and sunbathing during the hot hours of the day are strong risk factors in the three countries, but not the number of years spent outdoors, as farmers or building workers. Multiple logistic adjustments on the host characteristics increases the CMM risk associated with recreational exposure to sunlight, as well as the adjustment on the unawareness of the dangers of exaggerated exposure to sunlight. Recreational exposure to sunlight and sunburn early in life seem capable of fostering the proliferation of pigmented lesions of the skin. Our data support the hypothesis that most CMM develop from pigmented lesions of the skin containing initiated melanocytes, and that the cell proliferation due to brutal, intermittent exposures to solar radiation amplifies the likelihood of a melanocyte entering into a malignant process.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0960-8931 UR - https://www.unboundmedicine.com/medline/citation/8069100/Recreational_exposure_to_sunlight_and_lack_of_information_as_risk_factors_for_cutaneous_malignant_melanoma__Results_of_an_European_Organization_for_Research_and_Treatment_of_Cancer__EORTC__case_control_study_in_Belgium_France_and_Germany__The_EORTC_Malignant_Melanoma_Cooperative_Group_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8069100.ui DB - PRIME DP - Unbound Medicine ER -