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Maternal insulin-like growth factor-I infusion alters feto-placental carbohydrate and protein metabolism in pregnant sheep.
Endocrinology 1994; 135(3):895-900E

Abstract

Insulin-like growth factor-I (IGF-I) in the maternal circulation may have a role in the regulation of placental function and fetal growth, but its mechanisms of action are not known. We studied the effects of maternal IGF-I infusion (30 micrograms/kg.h for 4 h) in eight chronically catheterized pregnant sheep. IGF-I infusion caused an increase in fetal blood glucose concentrations, but no change in placental or fetal glucose uptake. Maternal plasma insulin concentrations fell. Placental lactate production increased by 56%, with most of this lactate taken up by the fetus. Maternal and fetal blood amino nitrogen concentrations fell, but fetal protein oxidation was unchanged. IGF-I infusion did not change feto-placental oxygenation, placental blood flow, or placental transfer by simple or facilitated diffusion. The metabolic effects of maternal IGF-I infusion in part oppose those of fetal IGF-I. We hypothesize that the balance of maternal and fetal IGF-I concentrations contributes to the regulation of substrate distribution between mother, placenta and fetus, and may thus mediate the nutritional regulation of fetal growth.

Authors+Show Affiliations

Research Center for Developmental Medicine and Biology, University of Auckland, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8070384

Citation

Liu, L, et al. "Maternal Insulin-like Growth factor-I Infusion Alters Feto-placental Carbohydrate and Protein Metabolism in Pregnant Sheep." Endocrinology, vol. 135, no. 3, 1994, pp. 895-900.
Liu L, Harding JE, Evans PC, et al. Maternal insulin-like growth factor-I infusion alters feto-placental carbohydrate and protein metabolism in pregnant sheep. Endocrinology. 1994;135(3):895-900.
Liu, L., Harding, J. E., Evans, P. C., & Gluckman, P. D. (1994). Maternal insulin-like growth factor-I infusion alters feto-placental carbohydrate and protein metabolism in pregnant sheep. Endocrinology, 135(3), pp. 895-900.
Liu L, et al. Maternal Insulin-like Growth factor-I Infusion Alters Feto-placental Carbohydrate and Protein Metabolism in Pregnant Sheep. Endocrinology. 1994;135(3):895-900. PubMed PMID: 8070384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal insulin-like growth factor-I infusion alters feto-placental carbohydrate and protein metabolism in pregnant sheep. AU - Liu,L, AU - Harding,J E, AU - Evans,P C, AU - Gluckman,P D, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 895 EP - 900 JF - Endocrinology JO - Endocrinology VL - 135 IS - 3 N2 - Insulin-like growth factor-I (IGF-I) in the maternal circulation may have a role in the regulation of placental function and fetal growth, but its mechanisms of action are not known. We studied the effects of maternal IGF-I infusion (30 micrograms/kg.h for 4 h) in eight chronically catheterized pregnant sheep. IGF-I infusion caused an increase in fetal blood glucose concentrations, but no change in placental or fetal glucose uptake. Maternal plasma insulin concentrations fell. Placental lactate production increased by 56%, with most of this lactate taken up by the fetus. Maternal and fetal blood amino nitrogen concentrations fell, but fetal protein oxidation was unchanged. IGF-I infusion did not change feto-placental oxygenation, placental blood flow, or placental transfer by simple or facilitated diffusion. The metabolic effects of maternal IGF-I infusion in part oppose those of fetal IGF-I. We hypothesize that the balance of maternal and fetal IGF-I concentrations contributes to the regulation of substrate distribution between mother, placenta and fetus, and may thus mediate the nutritional regulation of fetal growth. SN - 0013-7227 UR - https://www.unboundmedicine.com/medline/citation/8070384/Maternal_insulin_like_growth_factor_I_infusion_alters_feto_placental_carbohydrate_and_protein_metabolism_in_pregnant_sheep_ L2 - https://academic.oup.com/endo/article-lookup/doi/10.1210/endo.135.3.8070384 DB - PRIME DP - Unbound Medicine ER -