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Dietary habits and colorectal cancer in a low-risk area. Results from a population-based case-control study in southern Italy.
Nutr Cancer 1994; 21(3):233-46NC

Abstract

Many epidemiological studies have focused on the relationships between diet and colorectal cancer, but only a few have been conducted in the Mediterranean area. A population-based case-control study was carried out from July 1987 to June 1989 in a low-risk area in Southern Italy. By means of an "ad hoc" tumor registry, 132 diagnosed colorectal cancers were detected during the two years of study. One hundred nineteen of these 132 colorectal cancer cases were interviewed about their personal dietary habits with use of a questionnaire concerning the frequency of consumption of 70 foods or beverages. An equal number of controls was randomly selected from the lists of general practitioners of the area during the same period and interviewed with the same food frequency questionnaire. In a multivariate analysis, the relative risks (RRs) of developing colorectal cancer were estimated according to the different levels of consumption of food groups and selected food items. All RRs were adjusted for age, sex, education, smoking status, and modifications in diet in the previous 10 years. The risk of colorectal cancer increased nearly threefold for the highest level of consumption of foods with a high content of refined sugar [RR = 2.75, 95% confidence interval (CI) 1.26-5.97] and for the consumption of wine (> 1 l/day) (RR = 3.22, 95% CI 1.05-9.88). An inverse relationship was revealed for the highest consumption of raw and cooked vegetables (RR = 0.51, 95% CI 0.25-1.04) and diary products (RR = 0.46, 95% CI 0.22-0.98) and for the consumption of more than two cups of coffee per day (RR = 0.38, 95% CI 0.16-0.89). In this Mediterranean area, the main source of calories, cereals, did not show a significant relationship with colorectal cancer. These findings support the hypothesis that the local Mediterranean dietary pattern could explain the low risk of colorectal cancer.

Authors+Show Affiliations

Laboratorio di Epidemiologia e Biostatistica, IRCCS S. De Bellis, Castellana, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8072877

Citation

Centonze, S, et al. "Dietary Habits and Colorectal Cancer in a Low-risk Area. Results From a Population-based Case-control Study in Southern Italy." Nutrition and Cancer, vol. 21, no. 3, 1994, pp. 233-46.
Centonze S, Boeing H, Leoci C, et al. Dietary habits and colorectal cancer in a low-risk area. Results from a population-based case-control study in southern Italy. Nutr Cancer. 1994;21(3):233-46.
Centonze, S., Boeing, H., Leoci, C., Guerra, V., & Misciagna, G. (1994). Dietary habits and colorectal cancer in a low-risk area. Results from a population-based case-control study in southern Italy. Nutrition and Cancer, 21(3), pp. 233-46.
Centonze S, et al. Dietary Habits and Colorectal Cancer in a Low-risk Area. Results From a Population-based Case-control Study in Southern Italy. Nutr Cancer. 1994;21(3):233-46. PubMed PMID: 8072877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary habits and colorectal cancer in a low-risk area. Results from a population-based case-control study in southern Italy. AU - Centonze,S, AU - Boeing,H, AU - Leoci,C, AU - Guerra,V, AU - Misciagna,G, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 233 EP - 46 JF - Nutrition and cancer JO - Nutr Cancer VL - 21 IS - 3 N2 - Many epidemiological studies have focused on the relationships between diet and colorectal cancer, but only a few have been conducted in the Mediterranean area. A population-based case-control study was carried out from July 1987 to June 1989 in a low-risk area in Southern Italy. By means of an "ad hoc" tumor registry, 132 diagnosed colorectal cancers were detected during the two years of study. One hundred nineteen of these 132 colorectal cancer cases were interviewed about their personal dietary habits with use of a questionnaire concerning the frequency of consumption of 70 foods or beverages. An equal number of controls was randomly selected from the lists of general practitioners of the area during the same period and interviewed with the same food frequency questionnaire. In a multivariate analysis, the relative risks (RRs) of developing colorectal cancer were estimated according to the different levels of consumption of food groups and selected food items. All RRs were adjusted for age, sex, education, smoking status, and modifications in diet in the previous 10 years. The risk of colorectal cancer increased nearly threefold for the highest level of consumption of foods with a high content of refined sugar [RR = 2.75, 95% confidence interval (CI) 1.26-5.97] and for the consumption of wine (> 1 l/day) (RR = 3.22, 95% CI 1.05-9.88). An inverse relationship was revealed for the highest consumption of raw and cooked vegetables (RR = 0.51, 95% CI 0.25-1.04) and diary products (RR = 0.46, 95% CI 0.22-0.98) and for the consumption of more than two cups of coffee per day (RR = 0.38, 95% CI 0.16-0.89). In this Mediterranean area, the main source of calories, cereals, did not show a significant relationship with colorectal cancer. These findings support the hypothesis that the local Mediterranean dietary pattern could explain the low risk of colorectal cancer. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/8072877/Dietary_habits_and_colorectal_cancer_in_a_low_risk_area__Results_from_a_population_based_case_control_study_in_southern_Italy_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635589409514322 DB - PRIME DP - Unbound Medicine ER -