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Interlamellar lipid differences between normal and psoriatic stratum corneum.

Abstract

Intercellular lipids of the stratum corneum are involved in permeability barrier integrity and function. In psoriasis, desquamation and permeability barrier homeostasis are modified; these observations are consistent with an alteration in stratum corneum lipid production. Therefore, in the present study, we determined and compared the total content of the three main intercellular lipids in psoriatic scales and normal human stratum corneum. Our results showed that the relative free fatty acid content decreased remarkably (46%) in psoriatic scales, compared with normal human stratum corneum. This decrease may reflect a general state of emergency of keratinocytes, in which free fatty acids can be employed.

Authors+Show Affiliations

1st Clinic of Dermatology, University of Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8073812

Citation

Motta, S, et al. "Interlamellar Lipid Differences Between Normal and Psoriatic Stratum Corneum." Acta Dermato-venereologica. Supplementum, vol. 186, 1994, pp. 131-2.
Motta S, Sesana S, Monti M, et al. Interlamellar lipid differences between normal and psoriatic stratum corneum. Acta Derm Venereol Suppl (Stockh). 1994;186:131-2.
Motta, S., Sesana, S., Monti, M., Giuliani, A., & Caputo, R. (1994). Interlamellar lipid differences between normal and psoriatic stratum corneum. Acta Dermato-venereologica. Supplementum, 186, 131-2.
Motta S, et al. Interlamellar Lipid Differences Between Normal and Psoriatic Stratum Corneum. Acta Derm Venereol Suppl (Stockh). 1994;186:131-2. PubMed PMID: 8073812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interlamellar lipid differences between normal and psoriatic stratum corneum. AU - Motta,S, AU - Sesana,S, AU - Monti,M, AU - Giuliani,A, AU - Caputo,R, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 131 EP - 2 JF - Acta dermato-venereologica. Supplementum JO - Acta Derm Venereol Suppl (Stockh) VL - 186 N2 - Intercellular lipids of the stratum corneum are involved in permeability barrier integrity and function. In psoriasis, desquamation and permeability barrier homeostasis are modified; these observations are consistent with an alteration in stratum corneum lipid production. Therefore, in the present study, we determined and compared the total content of the three main intercellular lipids in psoriatic scales and normal human stratum corneum. Our results showed that the relative free fatty acid content decreased remarkably (46%) in psoriatic scales, compared with normal human stratum corneum. This decrease may reflect a general state of emergency of keratinocytes, in which free fatty acids can be employed. SN - 0365-8341 UR - https://www.unboundmedicine.com/medline/citation/8073812/Interlamellar_lipid_differences_between_normal_and_psoriatic_stratum_corneum_ L2 - https://medlineplus.gov/psoriasis.html DB - PRIME DP - Unbound Medicine ER -