Tags

Type your tag names separated by a space and hit enter

Individual responsiveness to a cholesterol-lowering diet in postmenopausal women with moderate hypercholesterolemia.
Arch Intern Med. 1994 Sep 12; 154(17):1977-82.AI

Abstract

BACKGROUND

The efficacy of the step 1 diet in outpatient women with hypercholesterolemia has been debated.

METHODS

Forty-one normotriglyceridemic women whose low-density lipoprotein (LDL) cholesterol levels were 3.62 to 5.17 mmol/L (140 to 200 mg/dL) participated in a two-period outpatient diet counseling study that used a 1-month high-fat, high-saturated fatty acid period (Hi-Sat diet) and a 4-month low-fat, low-saturated fatty acid period (step 1 diet). All women were postmenopausal and were not taking hormone replacement therapy. Levels of lipids, lipoproteins, and plasma triglyceride fatty acids were measured five times during the last 2 weeks of each dietary period. Dietary intake was assessed by 7-day food records.

RESULTS

The mean reduction in total cholesterol level achieved by the step 1 diet was 0.36 mmol/L (14 mg/dL). The reduction in total cholesterol level was seen in both LDL cholesterol levels (0.28 mmol/L [11 mg/dL]; P < .005) and high-density lipoprotein cholesterol levels (0.08 mmol/L [3 mg/dL]; P = .08). Although individual LDL responsiveness to diet was normally distributed, there was marked variation in response, which could be explained only partially by compliance (change in saturated fat intake, 10%), change in body weight (3%), and an interaction between the palmitic acid content of the plasma and body weight (3%).

CONCLUSIONS

A step 1 diet lowers total and LDL cholesterol levels in postmenopausal women. A nonsignificant reduction in high-density lipoprotein cholesterol levels was also observed. Since some women achieved LDL cholesterol levels low enough to obviate the need for drug therapy as primary prevention of coronary heart disease, dietary therapy should remain the first step in the management of hypercholesterolemia in postmenopausal women.

Authors+Show Affiliations

Center for Human Nutrition, University of Texas, Southwestern Medical Center at Dallas.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8074602

Citation

Denke, M A.. "Individual Responsiveness to a Cholesterol-lowering Diet in Postmenopausal Women With Moderate Hypercholesterolemia." Archives of Internal Medicine, vol. 154, no. 17, 1994, pp. 1977-82.
Denke MA. Individual responsiveness to a cholesterol-lowering diet in postmenopausal women with moderate hypercholesterolemia. Arch Intern Med. 1994;154(17):1977-82.
Denke, M. A. (1994). Individual responsiveness to a cholesterol-lowering diet in postmenopausal women with moderate hypercholesterolemia. Archives of Internal Medicine, 154(17), 1977-82.
Denke MA. Individual Responsiveness to a Cholesterol-lowering Diet in Postmenopausal Women With Moderate Hypercholesterolemia. Arch Intern Med. 1994 Sep 12;154(17):1977-82. PubMed PMID: 8074602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Individual responsiveness to a cholesterol-lowering diet in postmenopausal women with moderate hypercholesterolemia. A1 - Denke,M A, PY - 1994/9/12/pubmed PY - 1994/9/12/medline PY - 1994/9/12/entrez SP - 1977 EP - 82 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 154 IS - 17 N2 - BACKGROUND: The efficacy of the step 1 diet in outpatient women with hypercholesterolemia has been debated. METHODS: Forty-one normotriglyceridemic women whose low-density lipoprotein (LDL) cholesterol levels were 3.62 to 5.17 mmol/L (140 to 200 mg/dL) participated in a two-period outpatient diet counseling study that used a 1-month high-fat, high-saturated fatty acid period (Hi-Sat diet) and a 4-month low-fat, low-saturated fatty acid period (step 1 diet). All women were postmenopausal and were not taking hormone replacement therapy. Levels of lipids, lipoproteins, and plasma triglyceride fatty acids were measured five times during the last 2 weeks of each dietary period. Dietary intake was assessed by 7-day food records. RESULTS: The mean reduction in total cholesterol level achieved by the step 1 diet was 0.36 mmol/L (14 mg/dL). The reduction in total cholesterol level was seen in both LDL cholesterol levels (0.28 mmol/L [11 mg/dL]; P < .005) and high-density lipoprotein cholesterol levels (0.08 mmol/L [3 mg/dL]; P = .08). Although individual LDL responsiveness to diet was normally distributed, there was marked variation in response, which could be explained only partially by compliance (change in saturated fat intake, 10%), change in body weight (3%), and an interaction between the palmitic acid content of the plasma and body weight (3%). CONCLUSIONS: A step 1 diet lowers total and LDL cholesterol levels in postmenopausal women. A nonsignificant reduction in high-density lipoprotein cholesterol levels was also observed. Since some women achieved LDL cholesterol levels low enough to obviate the need for drug therapy as primary prevention of coronary heart disease, dietary therapy should remain the first step in the management of hypercholesterolemia in postmenopausal women. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/8074602/Individual_responsiveness_to_a_cholesterol_lowering_diet_in_postmenopausal_women_with_moderate_hypercholesterolemia_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/154/pg/1977 DB - PRIME DP - Unbound Medicine ER -