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Na-K-ATPase activity in the guinea pig stria vascularis in experimentally-induced endolymphatic hydrops.
Histol Histopathol. 1994 Apr; 9(2):205-9.HH

Abstract

The effect of endolymphatic hydrops on the Na-K-ATPase activity in the guinea pig stria vascularis was electron microscopically and enzyme cytochemically investigated one year after experimental induction. The morphological observations revealed intercellular dropsy in the basal infoldings of the marginal cells, and shrinkage and disappearance of intermediate cells. Moreover, shrinkage of the marginal cells, especially of the basal infoldings, was occasionally observed. In spite of these morphological alterations, the Na-K-ATPase activity was still detected on the plasma membrane of the basal infoldings of most marginal cells. No remarkable differences were found among the cochlear turns of the specimens examined. However, no reaction product was detected on the basolateral plasma membrane of severely degenerated marginal cells. The present results indicate that the Na-K-ATPase of the plasma membrane of the basal infoldings of the marginal cells plays an important role in the maintenance of the unique ion concentration of the endolymph even in the endolymphatic hydropic condition, and that the Na-K-ATPase activity is attenuated in severely atrophic cells.

Authors+Show Affiliations

Department of Otolaryngology, Kochi Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8075476

Citation

Nishiyama, S, et al. "Na-K-ATPase Activity in the Guinea Pig Stria Vascularis in Experimentally-induced Endolymphatic Hydrops." Histology and Histopathology, vol. 9, no. 2, 1994, pp. 205-9.
Nishiyama S, Okada T, Kobayashi T, et al. Na-K-ATPase activity in the guinea pig stria vascularis in experimentally-induced endolymphatic hydrops. Histol Histopathol. 1994;9(2):205-9.
Nishiyama, S., Okada, T., Kobayashi, T., Garcia del Saz, E., & Seguchi, H. (1994). Na-K-ATPase activity in the guinea pig stria vascularis in experimentally-induced endolymphatic hydrops. Histology and Histopathology, 9(2), 205-9.
Nishiyama S, et al. Na-K-ATPase Activity in the Guinea Pig Stria Vascularis in Experimentally-induced Endolymphatic Hydrops. Histol Histopathol. 1994;9(2):205-9. PubMed PMID: 8075476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Na-K-ATPase activity in the guinea pig stria vascularis in experimentally-induced endolymphatic hydrops. AU - Nishiyama,S, AU - Okada,T, AU - Kobayashi,T, AU - Garcia del Saz,E, AU - Seguchi,H, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 205 EP - 9 JF - Histology and histopathology JO - Histol Histopathol VL - 9 IS - 2 N2 - The effect of endolymphatic hydrops on the Na-K-ATPase activity in the guinea pig stria vascularis was electron microscopically and enzyme cytochemically investigated one year after experimental induction. The morphological observations revealed intercellular dropsy in the basal infoldings of the marginal cells, and shrinkage and disappearance of intermediate cells. Moreover, shrinkage of the marginal cells, especially of the basal infoldings, was occasionally observed. In spite of these morphological alterations, the Na-K-ATPase activity was still detected on the plasma membrane of the basal infoldings of most marginal cells. No remarkable differences were found among the cochlear turns of the specimens examined. However, no reaction product was detected on the basolateral plasma membrane of severely degenerated marginal cells. The present results indicate that the Na-K-ATPase of the plasma membrane of the basal infoldings of the marginal cells plays an important role in the maintenance of the unique ion concentration of the endolymph even in the endolymphatic hydropic condition, and that the Na-K-ATPase activity is attenuated in severely atrophic cells. SN - 0213-3911 UR - https://www.unboundmedicine.com/medline/citation/8075476/Na_K_ATPase_activity_in_the_guinea_pig_stria_vascularis_in_experimentally_induced_endolymphatic_hydrops_ L2 - https://medlineplus.gov/lymphaticdiseases.html DB - PRIME DP - Unbound Medicine ER -