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Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease.
Nat Genet. 1994 May; 7(1):74-8.NGen

Abstract

Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia.

Authors+Show Affiliations

Department of Epidemiology & Biostatistics, Erasmus University, Medical School, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8075646

Citation

van Duijn, C M., et al. "Apolipoprotein E4 Allele in a Population-based Study of Early-onset Alzheimer's Disease." Nature Genetics, vol. 7, no. 1, 1994, pp. 74-8.
van Duijn CM, de Knijff P, Cruts M, et al. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet. 1994;7(1):74-8.
van Duijn, C. M., de Knijff, P., Cruts, M., Wehnert, A., Havekes, L. M., Hofman, A., & Van Broeckhoven, C. (1994). Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nature Genetics, 7(1), 74-8.
van Duijn CM, et al. Apolipoprotein E4 Allele in a Population-based Study of Early-onset Alzheimer's Disease. Nat Genet. 1994;7(1):74-8. PubMed PMID: 8075646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. AU - van Duijn,C M, AU - de Knijff,P, AU - Cruts,M, AU - Wehnert,A, AU - Havekes,L M, AU - Hofman,A, AU - Van Broeckhoven,C, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 74 EP - 8 JF - Nature genetics JO - Nat. Genet. VL - 7 IS - 1 N2 - Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia. SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/8075646/Apolipoprotein_E4_allele_in_a_population_based_study_of_early_onset_Alzheimer's_disease_ L2 - http://dx.doi.org/10.1038/ng0594-74 DB - PRIME DP - Unbound Medicine ER -