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[Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in HIV-infected patients].
Dtsch Med Wochenschr. 1994 Aug 26; 119(34-35):1151-5.DM

Abstract

To assess the sensitivity and negative predictive value of sputum examination for Pneumocystis carinii in HIV-positive patients, follow-ups were performed in HIV-infected patients who had been investigated for the presence of Pneumocystis carinii (376 examinations of sputum and 71 bronchoalveolar lavages). Pneumocystis carinii pneumonia was diagnosed 65 times in 64 patients (57 male and 7 female, median age 35 [23-67]years). In 52% of the cases (n = 34) the pathogen was identified in the sputum, in 48% (n = 31) by means of the bronchoalveolar lavage. Of 342 negative findings in sputum examination, five were definitely false negative since the subsequent lavage yielded pneumocysts. In nine further cases Pneumocystis carinii pneumonia could not be excluded because of the course of the disease. In patients from whom sputum samples were available the sensitivity of pathogen identification was at least 70.8% and the negative predictive value at least 95.9%. Since preceding prophylaxis did not render identification in the sputum more difficult, examination of spontaneous or provoked sputum is indicated as a first hand measure in all patients infected with HIV in whom Pneumocystis carinii pneumonia is suspected.

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Authors+Show Affiliations

Schlatter CE
Departement Innere Medizin, Universitätsspital Zürich.
Kuster H
No affiliation info available
Lüthy R
No affiliation info available
Weber R
No affiliation info available
Russi EW
No affiliation info available
Opravil M
No affiliation info available

MeSH

AIDS-Related Opportunistic InfectionsAdultAgedBronchoalveolar Lavage FluidChi-Square DistributionFalse Negative ReactionsFemaleFollow-Up StudiesHIV InfectionsHIV-1HumansMaleMiddle AgedPneumocystisPneumonia, PneumocystisRetrospective StudiesSensitivity and SpecificitySputumSwitzerland

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

8076502

Citation

Schlatter, C E., et al. "[Sputum Examination in the Diagnosis of Pneumocystis Carinii Pneumonia in HIV-infected Patients]." Deutsche Medizinische Wochenschrift (1946), vol. 119, no. 34-35, 1994, pp. 1151-5.
Schlatter CE, Kuster H, Lüthy R, et al. [Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in HIV-infected patients]. Dtsch Med Wochenschr. 1994;119(34-35):1151-5.
Schlatter, C. E., Kuster, H., Lüthy, R., Weber, R., Russi, E. W., & Opravil, M. (1994). [Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in HIV-infected patients]. Deutsche Medizinische Wochenschrift (1946), 119(34-35), 1151-5.
Schlatter CE, et al. [Sputum Examination in the Diagnosis of Pneumocystis Carinii Pneumonia in HIV-infected Patients]. Dtsch Med Wochenschr. 1994 Aug 26;119(34-35):1151-5. PubMed PMID: 8076502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in HIV-infected patients]. AU - Schlatter,C E, AU - Kuster,H, AU - Lüthy,R, AU - Weber,R, AU - Russi,E W, AU - Opravil,M, PY - 1994/8/26/pubmed PY - 1994/8/26/medline PY - 1994/8/26/entrez SP - 1151 EP - 5 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 119 IS - 34-35 N2 - To assess the sensitivity and negative predictive value of sputum examination for Pneumocystis carinii in HIV-positive patients, follow-ups were performed in HIV-infected patients who had been investigated for the presence of Pneumocystis carinii (376 examinations of sputum and 71 bronchoalveolar lavages). Pneumocystis carinii pneumonia was diagnosed 65 times in 64 patients (57 male and 7 female, median age 35 [23-67]years). In 52% of the cases (n = 34) the pathogen was identified in the sputum, in 48% (n = 31) by means of the bronchoalveolar lavage. Of 342 negative findings in sputum examination, five were definitely false negative since the subsequent lavage yielded pneumocysts. In nine further cases Pneumocystis carinii pneumonia could not be excluded because of the course of the disease. In patients from whom sputum samples were available the sensitivity of pathogen identification was at least 70.8% and the negative predictive value at least 95.9%. Since preceding prophylaxis did not render identification in the sputum more difficult, examination of spontaneous or provoked sputum is indicated as a first hand measure in all patients infected with HIV in whom Pneumocystis carinii pneumonia is suspected. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/8076502/[Sputum_examination_in_the_diagnosis_of_Pneumocystis_carinii_pneumonia_in_HIV_infected_patients]_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1058815 DB - PRIME DP - Unbound Medicine ER -