Tags

Type your tag names separated by a space and hit enter

The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.
J Clin Endocrinol Metab. 1994 Sep; 79(3):703-6.JC

Abstract

The effects of the 5 alpha-reductase inhibitor, finasteride, on scalp skin testosterone (T) and dihydrotestosterone (DHT) levels were studied in patients with male pattern baldness. In a double blind study, male patients undergoing hair transplantation were treated with oral finasteride (5 mg/day) or placebo for 28 days. Scalp skin biopsies were obtained before and after treatment for measurement of T and DHT by high pressure liquid chromatography-RIA. In 10 male subjects studied at baseline, mean (+/- SEM) DHT levels were significantly higher in bald (7.37 +/- 1.24 pmol/g) compared to hair-containing (4.20 +/- 0.65 pmol/g) scalp, whereas there was no difference in mean T levels at baseline. In bald scalp from 8 patients treated with finasteride, the mean DHT concentration decreased from 6.40 +/- 1.07 pmol/g at baseline to 3.62 +/- 0.38 pmol/g on day 28. Scalp T levels increased in 6 of 8 subjects treated with finasteride. Finasteride decreased the mean serum DHT concentration from 1.36 +/- 0.18 nmol/L (n = 8) at baseline to 0.46 +/- 0.10 nmol/L on day 28 and had no effect on serum T. There were no significant changes in scalp or serum T or DHT in placebo-treated patients. In this study, male subjects treated with 5 mg/day finasteride for 4 weeks had significantly decreased concentrations of DHT in bald scalp, resulting in a mean level similar to the baseline levels found in hair-containing scalp.

Links

Publisher Full Text

Authors+Show Affiliations

Dallob AL
Merck Research Laboratories, Rahway, New Jersey 07065.
Sadick NS
No affiliation info available
Unger W
No affiliation info available
Lipert S
No affiliation info available
Geissler LA
No affiliation info available
Gregoire SL
No affiliation info available
Nguyen HH
No affiliation info available
Moore EC
No affiliation info available
Tanaka WK
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAlopeciaDihydrotestosteroneDouble-Blind MethodFinasterideHumansMaleMiddle AgedScalpTestosterone

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8077349

Citation

Dallob, A L., et al. "The Effect of Finasteride, a 5 Alpha-reductase Inhibitor, On Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness." The Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 3, 1994, pp. 703-6.
Dallob AL, Sadick NS, Unger W, et al. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. J Clin Endocrinol Metab. 1994;79(3):703-6.
Dallob, A. L., Sadick, N. S., Unger, W., Lipert, S., Geissler, L. A., Gregoire, S. L., Nguyen, H. H., Moore, E. C., & Tanaka, W. K. (1994). The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism, 79(3), 703-6.
Dallob AL, et al. The Effect of Finasteride, a 5 Alpha-reductase Inhibitor, On Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness. J Clin Endocrinol Metab. 1994;79(3):703-6. PubMed PMID: 8077349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. AU - Dallob,A L, AU - Sadick,N S, AU - Unger,W, AU - Lipert,S, AU - Geissler,L A, AU - Gregoire,S L, AU - Nguyen,H H, AU - Moore,E C, AU - Tanaka,W K, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 703 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 79 IS - 3 N2 - The effects of the 5 alpha-reductase inhibitor, finasteride, on scalp skin testosterone (T) and dihydrotestosterone (DHT) levels were studied in patients with male pattern baldness. In a double blind study, male patients undergoing hair transplantation were treated with oral finasteride (5 mg/day) or placebo for 28 days. Scalp skin biopsies were obtained before and after treatment for measurement of T and DHT by high pressure liquid chromatography-RIA. In 10 male subjects studied at baseline, mean (+/- SEM) DHT levels were significantly higher in bald (7.37 +/- 1.24 pmol/g) compared to hair-containing (4.20 +/- 0.65 pmol/g) scalp, whereas there was no difference in mean T levels at baseline. In bald scalp from 8 patients treated with finasteride, the mean DHT concentration decreased from 6.40 +/- 1.07 pmol/g at baseline to 3.62 +/- 0.38 pmol/g on day 28. Scalp T levels increased in 6 of 8 subjects treated with finasteride. Finasteride decreased the mean serum DHT concentration from 1.36 +/- 0.18 nmol/L (n = 8) at baseline to 0.46 +/- 0.10 nmol/L on day 28 and had no effect on serum T. There were no significant changes in scalp or serum T or DHT in placebo-treated patients. In this study, male subjects treated with 5 mg/day finasteride for 4 weeks had significantly decreased concentrations of DHT in bald scalp, resulting in a mean level similar to the baseline levels found in hair-containing scalp. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/8077349/The_effect_of_finasteride_a_5_alpha_reductase_inhibitor_on_scalp_skin_testosterone_and_dihydrotestosterone_concentrations_in_patients_with_male_pattern_baldness_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.79.3.8077349 DB - PRIME DP - Unbound Medicine ER -