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Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women.
J Clin Endocrinol Metab. 1994 Sep; 79(3):831-5.JC

Abstract

An oral 5-mg dose of finasteride, a 5 alpha-reductase inhibitor, was administered for 3 months to 10 hirsute women to determine the effect on gonadotropin secretion, on basal and stimulated androgen secretion, and on hair growth. Hair growth was assessed by the Ferriman-Gallwey score. All of the above determinations were evaluated before and after 1 and/or 3 months of finasteride treatment. Basal and GnRH-stimulated gonadotropin secretions were not affected. Indeed, finasteride did not modify the pulsatility of LH secretion. No change was seen in estradiol, PRL, free testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex hormone-binding globulin concentrations. Serum concentrations of cortisol (F) were significantly reduced after 1 month of finasteride treatment. The F levels returned to pretreatment levels after 3 months. Plasma levels of dihydrotestosterone and 3 alpha-androstanediol glucuronide significantly decreased during finasteride treatment. A significant increase in testosterone concentrations was observed after 3 months. Finasteride did not modify the responses of testosterone, androstenedione, and dehydroepiandrosterone sulfate to ACTH-(1-24) injection. Conversely, finasteride blunted the F response to corticotropin stimulation. Three months of finasteride treatment significantly decreased the Ferriman-Gallwey score. In conclusion, finasteride significantly decreased dihydrotestosterone and hair growth in hirsute women without negatively affecting gonadotropin secretion.

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Authors+Show Affiliations

Fruzzetti F
Department of Obstetrics and Gynecology, University of Pisa, Italy.
de Lorenzo D
No affiliation info available
Parrini D
No affiliation info available
Ricci C
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdolescentAdultAndrogensAndrostane-3,17-diolCosyntropinDihydrotestosteroneFemaleFinasterideFollicle Stimulating HormoneHairHirsutismHumansHydrocortisoneLuteinizing HormonePeriodicityTestosterone

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8077369

Citation

Fruzzetti, F, et al. "Effects of Finasteride, a 5 Alpha-reductase Inhibitor, On Circulating Androgens and Gonadotropin Secretion in Hirsute Women." The Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 3, 1994, pp. 831-5.
Fruzzetti F, de Lorenzo D, Parrini D, et al. Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women. J Clin Endocrinol Metab. 1994;79(3):831-5.
Fruzzetti, F., de Lorenzo, D., Parrini, D., & Ricci, C. (1994). Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women. The Journal of Clinical Endocrinology and Metabolism, 79(3), 831-5.
Fruzzetti F, et al. Effects of Finasteride, a 5 Alpha-reductase Inhibitor, On Circulating Androgens and Gonadotropin Secretion in Hirsute Women. J Clin Endocrinol Metab. 1994;79(3):831-5. PubMed PMID: 8077369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women. AU - Fruzzetti,F, AU - de Lorenzo,D, AU - Parrini,D, AU - Ricci,C, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 831 EP - 5 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 79 IS - 3 N2 - An oral 5-mg dose of finasteride, a 5 alpha-reductase inhibitor, was administered for 3 months to 10 hirsute women to determine the effect on gonadotropin secretion, on basal and stimulated androgen secretion, and on hair growth. Hair growth was assessed by the Ferriman-Gallwey score. All of the above determinations were evaluated before and after 1 and/or 3 months of finasteride treatment. Basal and GnRH-stimulated gonadotropin secretions were not affected. Indeed, finasteride did not modify the pulsatility of LH secretion. No change was seen in estradiol, PRL, free testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex hormone-binding globulin concentrations. Serum concentrations of cortisol (F) were significantly reduced after 1 month of finasteride treatment. The F levels returned to pretreatment levels after 3 months. Plasma levels of dihydrotestosterone and 3 alpha-androstanediol glucuronide significantly decreased during finasteride treatment. A significant increase in testosterone concentrations was observed after 3 months. Finasteride did not modify the responses of testosterone, androstenedione, and dehydroepiandrosterone sulfate to ACTH-(1-24) injection. Conversely, finasteride blunted the F response to corticotropin stimulation. Three months of finasteride treatment significantly decreased the Ferriman-Gallwey score. In conclusion, finasteride significantly decreased dihydrotestosterone and hair growth in hirsute women without negatively affecting gonadotropin secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/8077369/Effects_of_finasteride_a_5_alpha_reductase_inhibitor_on_circulating_androgens_and_gonadotropin_secretion_in_hirsute_women_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.79.3.8077369 DB - PRIME DP - Unbound Medicine ER -