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Effects of alcohol consumption on antioxidant content and susceptibility of low-density lipoprotein to oxidative modification.
J Am Coll Nutr 1994; 13(3):237-42JA

Abstract

OBJECTIVE

The effects of moderate alcohol intake on antioxidant content of low-density lipoprotein (LDL) and the susceptibility of LDL to oxidative modification were examined in 12 healthy adult males.

DESIGN

Volunteers abstained from alcohol for 3 weeks and then 12 subjects (alcohol intake group) consumed alcohol (0.5 g/kg/day) as brandy for 4 weeks; 4 subjects (control abstinence group) did not consume any alcohol for the entire study.

RESULTS

In the alcohol intake group, plasma total cholesterol (TC), triglyceride (TG), phospholipids (PL), free cholesterol (FC) and apoprotein B (apoB) levels in LDL decreased significantly after alcohol intake; however, since TC/apoB, TG/apoB, PL/apoB and FC/apoB ratios did not change significantly, it is clear that LDL particle numbers decreased. Vitamin E and vitamin A levels in plasma, and vitamin E content of LDL also did not change significantly. Beta-carotene levels in plasma and in LDL decreased significantly in the alcohol intake group. In the abstinence group, lipid levels and vitamin levels did not change. Lag time before the onset of LDL oxidation and propagation rate of LDL oxidation in the alcohol intake group did not change significantly.

CONCLUSIONS

Moderate alcohol intake decreases particle numbers of LDL without any changes in chemical composition, vitamin E content and susceptibility of LDL to oxidative modification. However, beta-carotene content was decreased significantly by even moderate alcohol intake.

Authors+Show Affiliations

First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8077571

Citation

Suzukawa, M, et al. "Effects of Alcohol Consumption On Antioxidant Content and Susceptibility of Low-density Lipoprotein to Oxidative Modification." Journal of the American College of Nutrition, vol. 13, no. 3, 1994, pp. 237-42.
Suzukawa M, Ishikawa T, Yoshida H, et al. Effects of alcohol consumption on antioxidant content and susceptibility of low-density lipoprotein to oxidative modification. J Am Coll Nutr. 1994;13(3):237-42.
Suzukawa, M., Ishikawa, T., Yoshida, H., Hosoai, K., Nishio, E., Yamashita, T., ... Suzuki, K. (1994). Effects of alcohol consumption on antioxidant content and susceptibility of low-density lipoprotein to oxidative modification. Journal of the American College of Nutrition, 13(3), pp. 237-42.
Suzukawa M, et al. Effects of Alcohol Consumption On Antioxidant Content and Susceptibility of Low-density Lipoprotein to Oxidative Modification. J Am Coll Nutr. 1994;13(3):237-42. PubMed PMID: 8077571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of alcohol consumption on antioxidant content and susceptibility of low-density lipoprotein to oxidative modification. AU - Suzukawa,M, AU - Ishikawa,T, AU - Yoshida,H, AU - Hosoai,K, AU - Nishio,E, AU - Yamashita,T, AU - Nakamura,H, AU - Hashizume,N, AU - Suzuki,K, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 237 EP - 42 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 13 IS - 3 N2 - OBJECTIVE: The effects of moderate alcohol intake on antioxidant content of low-density lipoprotein (LDL) and the susceptibility of LDL to oxidative modification were examined in 12 healthy adult males. DESIGN: Volunteers abstained from alcohol for 3 weeks and then 12 subjects (alcohol intake group) consumed alcohol (0.5 g/kg/day) as brandy for 4 weeks; 4 subjects (control abstinence group) did not consume any alcohol for the entire study. RESULTS: In the alcohol intake group, plasma total cholesterol (TC), triglyceride (TG), phospholipids (PL), free cholesterol (FC) and apoprotein B (apoB) levels in LDL decreased significantly after alcohol intake; however, since TC/apoB, TG/apoB, PL/apoB and FC/apoB ratios did not change significantly, it is clear that LDL particle numbers decreased. Vitamin E and vitamin A levels in plasma, and vitamin E content of LDL also did not change significantly. Beta-carotene levels in plasma and in LDL decreased significantly in the alcohol intake group. In the abstinence group, lipid levels and vitamin levels did not change. Lag time before the onset of LDL oxidation and propagation rate of LDL oxidation in the alcohol intake group did not change significantly. CONCLUSIONS: Moderate alcohol intake decreases particle numbers of LDL without any changes in chemical composition, vitamin E content and susceptibility of LDL to oxidative modification. However, beta-carotene content was decreased significantly by even moderate alcohol intake. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/8077571/Effects_of_alcohol_consumption_on_antioxidant_content_and_susceptibility_of_low_density_lipoprotein_to_oxidative_modification_ L2 - https://medlineplus.gov/alcohol.html DB - PRIME DP - Unbound Medicine ER -