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Onchocerciasis in endemic and nonendemic populations: differences in clinical presentation and immunologic findings.
J Infect Dis. 1994 Sep; 170(3):736-41.JI

Abstract

To characterize the clinical and laboratory features of onchocerciasis in visitors to endemic areas and to compare them with those seen in endemic subjects, 20 returned visitors and 21 endemic subjects with onchocerciasis were evaluated. Dermatitis was the most frequent clinical finding among the returned visitors. None had nodules or eye disease and, in contrast to the endemic subjects, microfiladermia was often absent or of low density. All persons studied had antibody responses measurable by ELISA to both soluble Onchocerca volvulus antigen and a panel of diagnostic recombinant antigens. Eosinophil and IgE levels were significantly higher in the endemic group, as was the capacity of peripheral blood mononuclear cells from this group to produce the T helper cell-like cytokines interleukin-4 and -5. It is likely that the chronicity and intensity of infection in endemic subjects account for the clinical and immunologic differences observed between the 2 groups.

Authors+Show Affiliations

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8077740

Citation

McCarthy, J S., et al. "Onchocerciasis in Endemic and Nonendemic Populations: Differences in Clinical Presentation and Immunologic Findings." The Journal of Infectious Diseases, vol. 170, no. 3, 1994, pp. 736-41.
McCarthy JS, Ottesen EA, Nutman TB. Onchocerciasis in endemic and nonendemic populations: differences in clinical presentation and immunologic findings. J Infect Dis. 1994;170(3):736-41.
McCarthy, J. S., Ottesen, E. A., & Nutman, T. B. (1994). Onchocerciasis in endemic and nonendemic populations: differences in clinical presentation and immunologic findings. The Journal of Infectious Diseases, 170(3), 736-41.
McCarthy JS, Ottesen EA, Nutman TB. Onchocerciasis in Endemic and Nonendemic Populations: Differences in Clinical Presentation and Immunologic Findings. J Infect Dis. 1994;170(3):736-41. PubMed PMID: 8077740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Onchocerciasis in endemic and nonendemic populations: differences in clinical presentation and immunologic findings. AU - McCarthy,J S, AU - Ottesen,E A, AU - Nutman,T B, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 736 EP - 41 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 170 IS - 3 N2 - To characterize the clinical and laboratory features of onchocerciasis in visitors to endemic areas and to compare them with those seen in endemic subjects, 20 returned visitors and 21 endemic subjects with onchocerciasis were evaluated. Dermatitis was the most frequent clinical finding among the returned visitors. None had nodules or eye disease and, in contrast to the endemic subjects, microfiladermia was often absent or of low density. All persons studied had antibody responses measurable by ELISA to both soluble Onchocerca volvulus antigen and a panel of diagnostic recombinant antigens. Eosinophil and IgE levels were significantly higher in the endemic group, as was the capacity of peripheral blood mononuclear cells from this group to produce the T helper cell-like cytokines interleukin-4 and -5. It is likely that the chronicity and intensity of infection in endemic subjects account for the clinical and immunologic differences observed between the 2 groups. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/8077740/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/170.3.736 DB - PRIME DP - Unbound Medicine ER -