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Endocrine function in alcoholic Korsakoff's syndrome.
Alcohol Alcohol. 1994 Mar; 29(2):187-91.AA

Abstract

Hypothalamic-pituitary function was studied by means of several dynamic endocrine tests in 19 patients with alcoholic Korsakoff's syndrome, 17 non-amnesic alcoholics and 21 non-alcoholic controls. The responses of thyroid stimulating hormone, prolactin, follicle stimulating hormone, and luteinizing hormone to a combined thyrotropin releasing hormone and gonadoliberin stimulation test did not differ significantly. For the dexamethasone suppression test, the Korsakoff patients had significantly higher basal serum cortisol and 08:00 hr post-dexamethasone cortisol levels than non-alcoholic controls. These findings raise the possibility that chronically elevated cortisol levels may contribute to cognitive impairment in alcoholic Korsakoff's syndrome.

Authors+Show Affiliations

Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8080600

Citation

Emsley, R A., et al. "Endocrine Function in Alcoholic Korsakoff's Syndrome." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 29, no. 2, 1994, pp. 187-91.
Emsley RA, Roberts MC, Aalbers C, et al. Endocrine function in alcoholic Korsakoff's syndrome. Alcohol Alcohol. 1994;29(2):187-91.
Emsley, R. A., Roberts, M. C., Aalbers, C., Taljaard, F. J., & Kotze, T. J. (1994). Endocrine function in alcoholic Korsakoff's syndrome. Alcohol and Alcoholism (Oxford, Oxfordshire), 29(2), 187-91.
Emsley RA, et al. Endocrine Function in Alcoholic Korsakoff's Syndrome. Alcohol Alcohol. 1994;29(2):187-91. PubMed PMID: 8080600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine function in alcoholic Korsakoff's syndrome. AU - Emsley,R A, AU - Roberts,M C, AU - Aalbers,C, AU - Taljaard,F J, AU - Kotze,T J, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 187 EP - 91 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 29 IS - 2 N2 - Hypothalamic-pituitary function was studied by means of several dynamic endocrine tests in 19 patients with alcoholic Korsakoff's syndrome, 17 non-amnesic alcoholics and 21 non-alcoholic controls. The responses of thyroid stimulating hormone, prolactin, follicle stimulating hormone, and luteinizing hormone to a combined thyrotropin releasing hormone and gonadoliberin stimulation test did not differ significantly. For the dexamethasone suppression test, the Korsakoff patients had significantly higher basal serum cortisol and 08:00 hr post-dexamethasone cortisol levels than non-alcoholic controls. These findings raise the possibility that chronically elevated cortisol levels may contribute to cognitive impairment in alcoholic Korsakoff's syndrome. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/8080600/Endocrine_function_in_alcoholic_Korsakoff's_syndrome_ L2 - https://medlineplus.gov/alcoholusedisorderaud.html DB - PRIME DP - Unbound Medicine ER -