Tags

Type your tag names separated by a space and hit enter

Transitory endolymph leakage induced hearing loss and tinnitus: depolarization, biphasic shortening and loss of electromotility of outer hair cells.
Eur Arch Otorhinolaryngol 1994; 251(3):143-53EA

Abstract

There are types of deafness and tinnitus in which ruptures or massive changes in the ionic permeability of the membranes lining the endolymphatic space [e.g., of the reticular lamina (RL)] are believed to allow potassium-rich endolymph to deluge the low [K+] perilymphatic fluid (e.g., in the small spaces of Nuel). This would result in a K+ intoxication of sensory and neural structures. Acute attacks of Ménière's disease have been suggested to be an important example for this event. The present study investigated the effects of transiently elevated [K+] due to the addition of artificial endolymph to the basolateral cell surface of outer hair cells (OHC) in replicating endolymph-induced K+ intoxication of the perilymph in the small spaces of Nuel. The influence of K+ intoxication of the basolateral OHC cell surface on the transduction was then examined. Intoxication resulted in an inhibition of the physiological repolarizing K+ efflux from hair cells. This induced unwanted depolarizations of the hair cells, interfering with mechanoelectrical transduction. A pathological longitudinal OHC shortening was also found, with subsequent compression of the organ of Corti possibly influencing the micromechanics of the mechanically active OHC. Both micromechanical and electrophysiological alterations are proposed to contribute to endolymph leakage induced attacks of deafness and possibly also to tinnitus. Moreover, repeated or long-lasting K+ intoxications of OHC resulted in a chronic and complete loss of OHC motility. This is suggested to be a pathophysiological basis in some patients with chronic hearing loss resulting from Ménière's syndrome.

Authors+Show Affiliations

Department of Otolaryngology, University of Tübingen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8080633

Citation

Zenner, H P., et al. "Transitory Endolymph Leakage Induced Hearing Loss and Tinnitus: Depolarization, Biphasic Shortening and Loss of Electromotility of Outer Hair Cells." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 251, no. 3, 1994, pp. 143-53.
Zenner HP, Reuter G, Zimmermann U, et al. Transitory endolymph leakage induced hearing loss and tinnitus: depolarization, biphasic shortening and loss of electromotility of outer hair cells. Eur Arch Otorhinolaryngol. 1994;251(3):143-53.
Zenner, H. P., Reuter, G., Zimmermann, U., Gitter, A. H., Fermin, C., & LePage, E. L. (1994). Transitory endolymph leakage induced hearing loss and tinnitus: depolarization, biphasic shortening and loss of electromotility of outer hair cells. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 251(3), pp. 143-53.
Zenner HP, et al. Transitory Endolymph Leakage Induced Hearing Loss and Tinnitus: Depolarization, Biphasic Shortening and Loss of Electromotility of Outer Hair Cells. Eur Arch Otorhinolaryngol. 1994;251(3):143-53. PubMed PMID: 8080633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transitory endolymph leakage induced hearing loss and tinnitus: depolarization, biphasic shortening and loss of electromotility of outer hair cells. AU - Zenner,H P, AU - Reuter,G, AU - Zimmermann,U, AU - Gitter,A H, AU - Fermin,C, AU - LePage,E L, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez KW - NASA Discipline Neuroscience KW - Non-NASA Center SP - 143 EP - 53 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 251 IS - 3 N2 - There are types of deafness and tinnitus in which ruptures or massive changes in the ionic permeability of the membranes lining the endolymphatic space [e.g., of the reticular lamina (RL)] are believed to allow potassium-rich endolymph to deluge the low [K+] perilymphatic fluid (e.g., in the small spaces of Nuel). This would result in a K+ intoxication of sensory and neural structures. Acute attacks of Ménière's disease have been suggested to be an important example for this event. The present study investigated the effects of transiently elevated [K+] due to the addition of artificial endolymph to the basolateral cell surface of outer hair cells (OHC) in replicating endolymph-induced K+ intoxication of the perilymph in the small spaces of Nuel. The influence of K+ intoxication of the basolateral OHC cell surface on the transduction was then examined. Intoxication resulted in an inhibition of the physiological repolarizing K+ efflux from hair cells. This induced unwanted depolarizations of the hair cells, interfering with mechanoelectrical transduction. A pathological longitudinal OHC shortening was also found, with subsequent compression of the organ of Corti possibly influencing the micromechanics of the mechanically active OHC. Both micromechanical and electrophysiological alterations are proposed to contribute to endolymph leakage induced attacks of deafness and possibly also to tinnitus. Moreover, repeated or long-lasting K+ intoxications of OHC resulted in a chronic and complete loss of OHC motility. This is suggested to be a pathophysiological basis in some patients with chronic hearing loss resulting from Ménière's syndrome. SN - 0937-4477 UR - https://www.unboundmedicine.com/medline/citation/8080633/Transitory_endolymph_leakage_induced_hearing_loss_and_tinnitus:_depolarization_biphasic_shortening_and_loss_of_electromotility_of_outer_hair_cells_ L2 - https://medlineplus.gov/hearingdisordersanddeafness.html DB - PRIME DP - Unbound Medicine ER -