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APC and p53 mutations in de novo colorectal adenocarcinomas.
Hum Mutat. 1994; 3(4):342-6.HM

Abstract

To investigate genetic features in small and flat colorectal carcinomas that arise de novo, we searched for genetic alterations in six sporadic tumors by examining their APC, K-ras, and p53 genes. Two of the six tumors carried detectable mutations within the mutation cluster region (MCR) of the APC gene; both mutations were predicted to cause truncation of the gene product. Four tumors carried mutations of the p53 gene; three were missense mutations in exon 5, and the other was a 3-bp deletion in exon 6. However, neither codon 12 nor codon 13 of K-ras contained detectable mutation in any tumors. Hence, as "adenoma-carcinoma sequence" model of development of colorectal carcinoma, inactivation of the APC and p53 genes appear to be involved in development of the de novo type of colorectal carcinoma even though the adenoma stage is not observed.

Authors+Show Affiliations

Department of Biochemistry, Cancer Institute, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8081386

Citation

Aoki, T, et al. "APC and P53 Mutations in De Novo Colorectal Adenocarcinomas." Human Mutation, vol. 3, no. 4, 1994, pp. 342-6.
Aoki T, Takeda S, Yanagisawa A, et al. APC and p53 mutations in de novo colorectal adenocarcinomas. Hum Mutat. 1994;3(4):342-6.
Aoki, T., Takeda, S., Yanagisawa, A., Kato, Y., Ajioka, Y., Watanabe, H., Kudo, S., & Nakamura, Y. (1994). APC and p53 mutations in de novo colorectal adenocarcinomas. Human Mutation, 3(4), 342-6.
Aoki T, et al. APC and P53 Mutations in De Novo Colorectal Adenocarcinomas. Hum Mutat. 1994;3(4):342-6. PubMed PMID: 8081386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - APC and p53 mutations in de novo colorectal adenocarcinomas. AU - Aoki,T, AU - Takeda,S, AU - Yanagisawa,A, AU - Kato,Y, AU - Ajioka,Y, AU - Watanabe,H, AU - Kudo,S, AU - Nakamura,Y, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 342 EP - 6 JF - Human mutation JO - Hum. Mutat. VL - 3 IS - 4 N2 - To investigate genetic features in small and flat colorectal carcinomas that arise de novo, we searched for genetic alterations in six sporadic tumors by examining their APC, K-ras, and p53 genes. Two of the six tumors carried detectable mutations within the mutation cluster region (MCR) of the APC gene; both mutations were predicted to cause truncation of the gene product. Four tumors carried mutations of the p53 gene; three were missense mutations in exon 5, and the other was a 3-bp deletion in exon 6. However, neither codon 12 nor codon 13 of K-ras contained detectable mutation in any tumors. Hence, as "adenoma-carcinoma sequence" model of development of colorectal carcinoma, inactivation of the APC and p53 genes appear to be involved in development of the de novo type of colorectal carcinoma even though the adenoma stage is not observed. SN - 1059-7794 UR - https://www.unboundmedicine.com/medline/citation/8081386/APC_and_p53_mutations_in_de_novo_colorectal_adenocarcinomas_ L2 - https://doi.org/10.1002/humu.1380030403 DB - PRIME DP - Unbound Medicine ER -