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Sucralfate mouth washing in the prevention of radiation-induced mucositis: a placebo-controlled double-blind randomized study.
Int J Radiat Oncol Biol Phys. 1994 Aug 30; 30(1):177-82.IJ

Abstract

PURPOSE

To evaluate the value of sucralfate mouth washings in prevention of radiation-induced mucositis.

METHODS AND MATERIALS

Forty patients with head and neck cancer were randomized to use either sucralfate mouth washing 1 g six times daily during irradiation (n = 20) or to placebo washing (n = 20). Mouth washing was started at the beginning of radiation therapy and continued to the end of the therapy (7-10 weeks). Assessment of the degree of radiation mucositis and collection of stimulated saliva samples were done weekly during the therapy. Salivary lactoferrin and albumin, suggested markers for the degree of mucositis, were analyzed from stimulated whole saliva samples.

RESULTS

All patients developed radiation-induced mucositis of varying degree after irradiation of about 30 Gy. No difference in the visually assessed degree of mucositis or oral pain reported by the patients was found between the study and the control groups. However, the patients treated with sucralfate used less anesthetic mouth washing and their salivary lactoferrin and albumin levels were lower.

CONCLUSION

Although the trial produced no direct clinical evidence indicating that sucralfate mouth rinses prevent radiation-induced mucositis, the decrease in the salivary lactoferrin and albumin levels suggests that sucralfate has a slight protective effect on the oral mucosa.

Authors+Show Affiliations

University of Turku, Department of Oral Surgery, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8083112

Citation

Makkonen, T A., et al. "Sucralfate Mouth Washing in the Prevention of Radiation-induced Mucositis: a Placebo-controlled Double-blind Randomized Study." International Journal of Radiation Oncology, Biology, Physics, vol. 30, no. 1, 1994, pp. 177-82.
Makkonen TA, Boström P, Vilja P, et al. Sucralfate mouth washing in the prevention of radiation-induced mucositis: a placebo-controlled double-blind randomized study. Int J Radiat Oncol Biol Phys. 1994;30(1):177-82.
Makkonen, T. A., Boström, P., Vilja, P., & Joensuu, H. (1994). Sucralfate mouth washing in the prevention of radiation-induced mucositis: a placebo-controlled double-blind randomized study. International Journal of Radiation Oncology, Biology, Physics, 30(1), 177-82.
Makkonen TA, et al. Sucralfate Mouth Washing in the Prevention of Radiation-induced Mucositis: a Placebo-controlled Double-blind Randomized Study. Int J Radiat Oncol Biol Phys. 1994 Aug 30;30(1):177-82. PubMed PMID: 8083112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sucralfate mouth washing in the prevention of radiation-induced mucositis: a placebo-controlled double-blind randomized study. AU - Makkonen,T A, AU - Boström,P, AU - Vilja,P, AU - Joensuu,H, PY - 1994/8/30/pubmed PY - 1994/8/30/medline PY - 1994/8/30/entrez SP - 177 EP - 82 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 30 IS - 1 N2 - PURPOSE: To evaluate the value of sucralfate mouth washings in prevention of radiation-induced mucositis. METHODS AND MATERIALS: Forty patients with head and neck cancer were randomized to use either sucralfate mouth washing 1 g six times daily during irradiation (n = 20) or to placebo washing (n = 20). Mouth washing was started at the beginning of radiation therapy and continued to the end of the therapy (7-10 weeks). Assessment of the degree of radiation mucositis and collection of stimulated saliva samples were done weekly during the therapy. Salivary lactoferrin and albumin, suggested markers for the degree of mucositis, were analyzed from stimulated whole saliva samples. RESULTS: All patients developed radiation-induced mucositis of varying degree after irradiation of about 30 Gy. No difference in the visually assessed degree of mucositis or oral pain reported by the patients was found between the study and the control groups. However, the patients treated with sucralfate used less anesthetic mouth washing and their salivary lactoferrin and albumin levels were lower. CONCLUSION: Although the trial produced no direct clinical evidence indicating that sucralfate mouth rinses prevent radiation-induced mucositis, the decrease in the salivary lactoferrin and albumin levels suggests that sucralfate has a slight protective effect on the oral mucosa. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/8083112/Sucralfate_mouth_washing_in_the_prevention_of_radiation_induced_mucositis:_a_placebo_controlled_double_blind_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0360-3016(94)90533-9 DB - PRIME DP - Unbound Medicine ER -