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Pathogenesis of mucocutaneous lesions in Behçet's disease.
J Dermatol. 1994 Jul; 21(7):474-80.JD

Abstract

Behçet's disease (BD) is characterized by recurrent oral aphthae, skin lesions, eye lesions, and genital ulceration. To determine the pathogenesis of BD, we performed histological and immunohistochemical studies of these mucocutaneous lesions, an assay of neutrophil activity, and HLA typing. Dense dermal or subcutaneous infiltrations of polymorphonuclear cells (PMN) without leukocytoclastic vasculitis were found in 28 of 57 lesions. Immunohistochemically, deposits of C3 on the vessels were found in 12 of 31 lesions. Deposits of immunoglobulin were not found except for one of IgM. C3 deposits and PMN infiltrations were significantly related (p < 0.05). PMN activity by polarization was enhanced; however, the results did not show a significant relationship with the PMN infiltrations or the C3 deposits. The incidence of HLA-B51 was significantly high in BD, but no significant relationship was found between HLA-B51 and the results of other examinations. These results suggest that the pathogenesis of BD lesions differs from that of collagen diseases and that C3 deposits on the vessels may play an important role in the development of mucocutaneous lesions where PMN have mainly infiltrated.

Authors+Show Affiliations

Department of Dermatology, St. Marianna Univeristy School of Medicine, Kawasaki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8089366

Citation

Inoue, C, et al. "Pathogenesis of Mucocutaneous Lesions in Behçet's Disease." The Journal of Dermatology, vol. 21, no. 7, 1994, pp. 474-80.
Inoue C, Itoh R, Kawa Y, et al. Pathogenesis of mucocutaneous lesions in Behçet's disease. J Dermatol. 1994;21(7):474-80.
Inoue, C., Itoh, R., Kawa, Y., & Mizoguchi, M. (1994). Pathogenesis of mucocutaneous lesions in Behçet's disease. The Journal of Dermatology, 21(7), 474-80.
Inoue C, et al. Pathogenesis of Mucocutaneous Lesions in Behçet's Disease. J Dermatol. 1994;21(7):474-80. PubMed PMID: 8089366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis of mucocutaneous lesions in Behçet's disease. AU - Inoue,C, AU - Itoh,R, AU - Kawa,Y, AU - Mizoguchi,M, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 474 EP - 80 JF - The Journal of dermatology JO - J. Dermatol. VL - 21 IS - 7 N2 - Behçet's disease (BD) is characterized by recurrent oral aphthae, skin lesions, eye lesions, and genital ulceration. To determine the pathogenesis of BD, we performed histological and immunohistochemical studies of these mucocutaneous lesions, an assay of neutrophil activity, and HLA typing. Dense dermal or subcutaneous infiltrations of polymorphonuclear cells (PMN) without leukocytoclastic vasculitis were found in 28 of 57 lesions. Immunohistochemically, deposits of C3 on the vessels were found in 12 of 31 lesions. Deposits of immunoglobulin were not found except for one of IgM. C3 deposits and PMN infiltrations were significantly related (p < 0.05). PMN activity by polarization was enhanced; however, the results did not show a significant relationship with the PMN infiltrations or the C3 deposits. The incidence of HLA-B51 was significantly high in BD, but no significant relationship was found between HLA-B51 and the results of other examinations. These results suggest that the pathogenesis of BD lesions differs from that of collagen diseases and that C3 deposits on the vessels may play an important role in the development of mucocutaneous lesions where PMN have mainly infiltrated. SN - 0385-2407 UR - https://www.unboundmedicine.com/medline/citation/8089366/Pathogenesis_of_mucocutaneous_lesions_in_Behçet's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0385-2407&amp;date=1994&amp;volume=21&amp;issue=7&amp;spage=474 DB - PRIME DP - Unbound Medicine ER -