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Role of transcobalamins I, II, and III in the transfer of vitamin B12 to human bone marrow cells in vitro.
Acta Haematol. 1975; 54(2):89-94.AH

Abstract

A study of the uptake of transcobalamin-bound 57Co-cyanocobalamin by suspensions of human bone marrow cells has indicated that these cells can take up vitamin B12 from all 3 transcobalamins (I, II, and III). Similar transport processes were involved in the uptake from the 3 transcobalamins; uptake was dependent on the presence of calcium ions, cellular respiration and free sulphydryl groups. These results suggest that contrary to current belief, all 3 transcobalamins play a role in the transfer of vitamin B12 to tissue cells.

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Authors

Wickramasinghe SN
No affiliation info available
England JM
No affiliation info available
Saunders JE
No affiliation info available
Down MC
No affiliation info available

MeSH

Biological TransportBlood ProteinsBone MarrowBone Marrow CellsCyanidesDepression, ChemicalEdetic AcidHumansIodoacetamideTranscobalaminsVitamin B 12

Pub Type(s)

Journal Article

Language

eng

PubMed ID

808945

Citation

Wickramasinghe, S N., et al. "Role of Transcobalamins I, II, and III in the Transfer of Vitamin B12 to Human Bone Marrow Cells in Vitro." Acta Haematologica, vol. 54, no. 2, 1975, pp. 89-94.
Wickramasinghe SN, England JM, Saunders JE, et al. Role of transcobalamins I, II, and III in the transfer of vitamin B12 to human bone marrow cells in vitro. Acta Haematol. 1975;54(2):89-94.
Wickramasinghe, S. N., England, J. M., Saunders, J. E., & Down, M. C. (1975). Role of transcobalamins I, II, and III in the transfer of vitamin B12 to human bone marrow cells in vitro. Acta Haematologica, 54(2), 89-94.
Wickramasinghe SN, et al. Role of Transcobalamins I, II, and III in the Transfer of Vitamin B12 to Human Bone Marrow Cells in Vitro. Acta Haematol. 1975;54(2):89-94. PubMed PMID: 808945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of transcobalamins I, II, and III in the transfer of vitamin B12 to human bone marrow cells in vitro. AU - Wickramasinghe,S N, AU - England,J M, AU - Saunders,J E, AU - Down,M C, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 89 EP - 94 JF - Acta haematologica JO - Acta Haematol VL - 54 IS - 2 N2 - A study of the uptake of transcobalamin-bound 57Co-cyanocobalamin by suspensions of human bone marrow cells has indicated that these cells can take up vitamin B12 from all 3 transcobalamins (I, II, and III). Similar transport processes were involved in the uptake from the 3 transcobalamins; uptake was dependent on the presence of calcium ions, cellular respiration and free sulphydryl groups. These results suggest that contrary to current belief, all 3 transcobalamins play a role in the transfer of vitamin B12 to tissue cells. SN - 0001-5792 UR - https://www.unboundmedicine.com/medline/citation/808945/Role_of_transcobalamins_I_II_and_III_in_the_transfer_of_vitamin_B12_to_human_bone_marrow_cells_in_vitro_ L2 - https://www.karger.com?DOI=10.1159/000208057 DB - PRIME DP - Unbound Medicine ER -