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Current concepts of the formation and composition of amyloid.
Ann Clin Lab Sci. 1975 Jul-Aug; 5(4):257-63.AC

Abstract

Immunochemical and chemical studies of purified amyloid fibril protein from a wide variety of human tissues reveals that amyloid fibrils may derive from immunoglobulin proteins most frequently in the "primary" disease and can be classified as of kappa- or lambda-type. In addition a protein of unknown origin is the source of amyloid fibrils in another group of cases usually of "secondary" type. The creation of fibrils with all the characteristics of amyloid fibrils has been accomplished by proteolysis of some Bence Jones proteins. This indicates that amyloid fibrils may be formed by proteolytic digestion of circulating light polypeptide chains of immunoglobulin proteins.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

808999

Citation

Glenner, G G.. "Current Concepts of the Formation and Composition of Amyloid." Annals of Clinical and Laboratory Science, vol. 5, no. 4, 1975, pp. 257-63.
Glenner GG. Current concepts of the formation and composition of amyloid. Ann Clin Lab Sci. 1975;5(4):257-63.
Glenner, G. G. (1975). Current concepts of the formation and composition of amyloid. Annals of Clinical and Laboratory Science, 5(4), 257-63.
Glenner GG. Current Concepts of the Formation and Composition of Amyloid. Ann Clin Lab Sci. 1975 Jul-Aug;5(4):257-63. PubMed PMID: 808999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current concepts of the formation and composition of amyloid. A1 - Glenner,G G, PY - 1975/7/1/pubmed PY - 1975/7/1/medline PY - 1975/7/1/entrez SP - 257 EP - 63 JF - Annals of clinical and laboratory science JO - Ann Clin Lab Sci VL - 5 IS - 4 N2 - Immunochemical and chemical studies of purified amyloid fibril protein from a wide variety of human tissues reveals that amyloid fibrils may derive from immunoglobulin proteins most frequently in the "primary" disease and can be classified as of kappa- or lambda-type. In addition a protein of unknown origin is the source of amyloid fibrils in another group of cases usually of "secondary" type. The creation of fibrils with all the characteristics of amyloid fibrils has been accomplished by proteolysis of some Bence Jones proteins. This indicates that amyloid fibrils may be formed by proteolytic digestion of circulating light polypeptide chains of immunoglobulin proteins. SN - 0091-7370 UR - https://www.unboundmedicine.com/medline/citation/808999/Current_concepts_of_the_formation_and_composition_of_amyloid_ DB - PRIME DP - Unbound Medicine ER -
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