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Incidence of the prozone phenomenon in syphilis serology.
Obstet Gynecol. 1994 Oct; 84(4):609-12.OG

Abstract

OBJECTIVE

To determine the rate of the prozone phenomenon in our patient population.

METHODS

Sera from 4328 patients--3504 females (2065 pregnant, 1439 nonpregnant) and 824 males--were tested for syphilis by the rapid plasma reagin (RPR) test, and then rechecked with serial twofold dilutions of up to 16-fold to detect the prozone phenomenon. Chi-square analysis with Yates correction was used, with P < or = .05 considered significant.

RESULTS

The total positivity rate in females was 6% (213 patients); 13% (27) of the positive tests were false-positive reactions as confirmed by a negative anti-treponemal antibody test. Only one prozone reaction was detected, in serum from a male subject, but it was not missed on initial screening.

CONCLUSION

The rate of prozone phenomenon is very low (95% confidence interval 0-0.4%), and routine serial dilutions are not cost effective.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8090401

Citation

el-Zaatari, M M., et al. "Incidence of the Prozone Phenomenon in Syphilis Serology." Obstetrics and Gynecology, vol. 84, no. 4, 1994, pp. 609-12.
el-Zaatari MM, Martens MG, Anderson GD. Incidence of the prozone phenomenon in syphilis serology. Obstet Gynecol. 1994;84(4):609-12.
el-Zaatari, M. M., Martens, M. G., & Anderson, G. D. (1994). Incidence of the prozone phenomenon in syphilis serology. Obstetrics and Gynecology, 84(4), 609-12.
el-Zaatari MM, Martens MG, Anderson GD. Incidence of the Prozone Phenomenon in Syphilis Serology. Obstet Gynecol. 1994;84(4):609-12. PubMed PMID: 8090401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of the prozone phenomenon in syphilis serology. AU - el-Zaatari,M M, AU - Martens,M G, AU - Anderson,G D, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 609 EP - 12 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 84 IS - 4 N2 - OBJECTIVE: To determine the rate of the prozone phenomenon in our patient population. METHODS: Sera from 4328 patients--3504 females (2065 pregnant, 1439 nonpregnant) and 824 males--were tested for syphilis by the rapid plasma reagin (RPR) test, and then rechecked with serial twofold dilutions of up to 16-fold to detect the prozone phenomenon. Chi-square analysis with Yates correction was used, with P < or = .05 considered significant. RESULTS: The total positivity rate in females was 6% (213 patients); 13% (27) of the positive tests were false-positive reactions as confirmed by a negative anti-treponemal antibody test. Only one prozone reaction was detected, in serum from a male subject, but it was not missed on initial screening. CONCLUSION: The rate of prozone phenomenon is very low (95% confidence interval 0-0.4%), and routine serial dilutions are not cost effective. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/8090401/Incidence_of_the_prozone_phenomenon_in_syphilis_serology_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8090401.ui DB - PRIME DP - Unbound Medicine ER -