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Immunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins.
Blood. 1975 Nov; 46(5):713-22.Blood

Abstract

Urinary Bence Jones protein and amyloid fibril protein isolated from the subcutaneous tissue of a patient with IgD myeloma and associated amyloidosis were subjected to physicochemical and immunochemical identification. Peptide maps and amino-terminal tetrapeptide composition obtained from the two proteins were comparable. Immunochemical cross-reactivity between the two proteins, with other lambda-type amyloid and Bence Jones proteins, and with a serum component was demonstrated. The results suggest that the source of the amyloid fibril protein is an intact circulating light polypeptide chain as well as smaller amino-terminal fragments.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

809071

Citation

White, G C., et al. "Immunoglobulin D Myeloma and Amyloidosis: Immunochemical and Structural Studies of Bence Jones and Amyloid Fibrillar Proteins." Blood, vol. 46, no. 5, 1975, pp. 713-22.
White GC, Jacobson RJ, Binder RA, et al. Immunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins. Blood. 1975;46(5):713-22.
White, G. C., Jacobson, R. J., Binder, R. A., Linke, R. P., & Glenner, G. G. (1975). Immunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins. Blood, 46(5), 713-22.
White GC, et al. Immunoglobulin D Myeloma and Amyloidosis: Immunochemical and Structural Studies of Bence Jones and Amyloid Fibrillar Proteins. Blood. 1975;46(5):713-22. PubMed PMID: 809071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins. AU - White,G C,2nd AU - Jacobson,R J, AU - Binder,R A, AU - Linke,R P, AU - Glenner,G G, PY - 1975/11/1/pubmed PY - 1975/11/1/medline PY - 1975/11/1/entrez SP - 713 EP - 22 JF - Blood JO - Blood VL - 46 IS - 5 N2 - Urinary Bence Jones protein and amyloid fibril protein isolated from the subcutaneous tissue of a patient with IgD myeloma and associated amyloidosis were subjected to physicochemical and immunochemical identification. Peptide maps and amino-terminal tetrapeptide composition obtained from the two proteins were comparable. Immunochemical cross-reactivity between the two proteins, with other lambda-type amyloid and Bence Jones proteins, and with a serum component was demonstrated. The results suggest that the source of the amyloid fibril protein is an intact circulating light polypeptide chain as well as smaller amino-terminal fragments. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/809071/Immunoglobulin_D_myeloma_and_amyloidosis:_immunochemical_and_structural_studies_of_Bence_Jones_and_amyloid_fibrillar_proteins_ L2 - https://ashpublications.org/blood/article-lookup/doi/&lo.doi; DB - PRIME DP - Unbound Medicine ER -