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Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-mo prospective study.
Am J Clin Nutr. 1994 Oct; 60(4):579-85.AJ

Abstract

To assess whether moderate dietary protein restriction can delay the progression of overt diabetic nephropathy, 22 subjects with insulin-dependent diabetes mellitus were randomly assigned to an unrestricted protein diet (> 1.6 g.kg body wt-1.d-1) or a moderately protein-restricted diet (0.8 g.kg body wt-1.d-1) and followed prospectively for six mo. Direct isotope methods were used to assess renal function. Protein intake was assessed by measurement of urinary urea nitrogen. The two groups were well-matched for age, sex, duration of diabetes, glycemic control, blood pressure, and degree of renal insufficiency. Patients consuming the unrestricted protein diet (n = 11) showed a progressive decline in glomerular filtration rate of 1.3 mL.min-1.mo-1 with no change in proteinuria. Patients consuming the moderately protein-restricted diet showed a marked decrease in the degree of proteinuria (2.15-1.13 g/d, P = 0.036) and a stabilization of glomerular filtration rate. This occurred independently of changes in blood pressure or glycemic control. Moderate dietary protein restriction can ameliorate progression of overt diabetic nephropathy.

Authors+Show Affiliations

Raal FJ
Division of Endocrinology and Metabolism, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Kalk WJ
No affiliation info available
Lawson M
No affiliation info available
Esser JD
No affiliation info available
Buys R
No affiliation info available
Fourie L
No affiliation info available
Panz VR
No affiliation info available

MeSH

AdultBlood GlucoseBlood PressureCholesterolDiabetes Mellitus, Type 1Diabetic NephropathiesDietary ProteinsFemaleGlomerular Filtration RateHumansMaleProspective StudiesProteinuriaTriglyceridesUrea

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8092094

Citation

Raal, F J., et al. "Effect of Moderate Dietary Protein Restriction On the Progression of Overt Diabetic Nephropathy: a 6-mo Prospective Study." The American Journal of Clinical Nutrition, vol. 60, no. 4, 1994, pp. 579-85.
Raal FJ, Kalk WJ, Lawson M, et al. Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-mo prospective study. Am J Clin Nutr. 1994;60(4):579-85.
Raal, F. J., Kalk, W. J., Lawson, M., Esser, J. D., Buys, R., Fourie, L., & Panz, V. R. (1994). Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-mo prospective study. The American Journal of Clinical Nutrition, 60(4), 579-85.
Raal FJ, et al. Effect of Moderate Dietary Protein Restriction On the Progression of Overt Diabetic Nephropathy: a 6-mo Prospective Study. Am J Clin Nutr. 1994;60(4):579-85. PubMed PMID: 8092094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-mo prospective study. AU - Raal,F J, AU - Kalk,W J, AU - Lawson,M, AU - Esser,J D, AU - Buys,R, AU - Fourie,L, AU - Panz,V R, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 579 EP - 85 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 60 IS - 4 N2 - To assess whether moderate dietary protein restriction can delay the progression of overt diabetic nephropathy, 22 subjects with insulin-dependent diabetes mellitus were randomly assigned to an unrestricted protein diet (> 1.6 g.kg body wt-1.d-1) or a moderately protein-restricted diet (0.8 g.kg body wt-1.d-1) and followed prospectively for six mo. Direct isotope methods were used to assess renal function. Protein intake was assessed by measurement of urinary urea nitrogen. The two groups were well-matched for age, sex, duration of diabetes, glycemic control, blood pressure, and degree of renal insufficiency. Patients consuming the unrestricted protein diet (n = 11) showed a progressive decline in glomerular filtration rate of 1.3 mL.min-1.mo-1 with no change in proteinuria. Patients consuming the moderately protein-restricted diet showed a marked decrease in the degree of proteinuria (2.15-1.13 g/d, P = 0.036) and a stabilization of glomerular filtration rate. This occurred independently of changes in blood pressure or glycemic control. Moderate dietary protein restriction can ameliorate progression of overt diabetic nephropathy. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8092094/Effect_of_moderate_dietary_protein_restriction_on_the_progression_of_overt_diabetic_nephropathy:_a_6_mo_prospective_study_ DB - PRIME DP - Unbound Medicine ER -