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Ability of a new infant formula prepared from partially hydrolyzed bovine whey to induce anaphylactic sensitization: evaluation in a guinea pig model.
Allergy 1994; 49(5):361-4A

Abstract

In the present study we evaluated the allergenicity and immunogenicity of a whey partially hydrolysate formula (PHF) in a guinea pig model. Nine groups of 10 guinea pigs received either a conventional milk formula (CMF) or PHF for 37 days. After intravenous (i.v.) challenge with either beta-lactoglobulin (beta-L) or ultracentrifuged (u)CMF, animals fed CMF showed, respectively, 80% and 100% fatal reactions, whereas animals fed PHF showed no reactions when i.v. challenged both with beta-L and uPHF. Eighty percent fatal reactions, and 10%, respectively, of severe and mild reactions have been observed in the CMF-fed, casein-challenge group. In contrast, only one (10%) mild reaction occurred in the PHF-fed, casein-challenged group. When challenged with u-pasteurized cow's milk (uPCM), CMF-fed animals showed 86% fatal reactions and 14% mild reactions, whereas PHF-fed ones presented 70% no reactions, 20% mild reactions, and one (10%) fatal reaction. Animals fed CMF showed a significantly higher level of specific IgG against cow's milk antigens than PHF-fed ones, which, however, presented higher levels of antibodies than a water-supplemented control group. The present results confirm that PHF is less sensitizing than CMF in a guinea pig model.

Authors+Show Affiliations

Pediatric Department, University of Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8092434

Citation

Piacentini, G L., et al. "Ability of a New Infant Formula Prepared From Partially Hydrolyzed Bovine Whey to Induce Anaphylactic Sensitization: Evaluation in a Guinea Pig Model." Allergy, vol. 49, no. 5, 1994, pp. 361-4.
Piacentini GL, Bertolini A, Spezia E, et al. Ability of a new infant formula prepared from partially hydrolyzed bovine whey to induce anaphylactic sensitization: evaluation in a guinea pig model. Allergy. 1994;49(5):361-4.
Piacentini, G. L., Bertolini, A., Spezia, E., Piscione, T., & Boner, A. L. (1994). Ability of a new infant formula prepared from partially hydrolyzed bovine whey to induce anaphylactic sensitization: evaluation in a guinea pig model. Allergy, 49(5), pp. 361-4.
Piacentini GL, et al. Ability of a New Infant Formula Prepared From Partially Hydrolyzed Bovine Whey to Induce Anaphylactic Sensitization: Evaluation in a Guinea Pig Model. Allergy. 1994;49(5):361-4. PubMed PMID: 8092434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ability of a new infant formula prepared from partially hydrolyzed bovine whey to induce anaphylactic sensitization: evaluation in a guinea pig model. AU - Piacentini,G L, AU - Bertolini,A, AU - Spezia,E, AU - Piscione,T, AU - Boner,A L, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 361 EP - 4 JF - Allergy JO - Allergy VL - 49 IS - 5 N2 - In the present study we evaluated the allergenicity and immunogenicity of a whey partially hydrolysate formula (PHF) in a guinea pig model. Nine groups of 10 guinea pigs received either a conventional milk formula (CMF) or PHF for 37 days. After intravenous (i.v.) challenge with either beta-lactoglobulin (beta-L) or ultracentrifuged (u)CMF, animals fed CMF showed, respectively, 80% and 100% fatal reactions, whereas animals fed PHF showed no reactions when i.v. challenged both with beta-L and uPHF. Eighty percent fatal reactions, and 10%, respectively, of severe and mild reactions have been observed in the CMF-fed, casein-challenge group. In contrast, only one (10%) mild reaction occurred in the PHF-fed, casein-challenged group. When challenged with u-pasteurized cow's milk (uPCM), CMF-fed animals showed 86% fatal reactions and 14% mild reactions, whereas PHF-fed ones presented 70% no reactions, 20% mild reactions, and one (10%) fatal reaction. Animals fed CMF showed a significantly higher level of specific IgG against cow's milk antigens than PHF-fed ones, which, however, presented higher levels of antibodies than a water-supplemented control group. The present results confirm that PHF is less sensitizing than CMF in a guinea pig model. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/8092434/Ability_of_a_new_infant_formula_prepared_from_partially_hydrolyzed_bovine_whey_to_induce_anaphylactic_sensitization:_evaluation_in_a_guinea_pig_model_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1994&volume=49&issue=5&spage=361 DB - PRIME DP - Unbound Medicine ER -