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Structure and expression of the promoter for the human type II transforming growth factor-beta receptor.
Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1020-7.BB

Abstract

The type II TGF-beta receptor is a serine/threonine kinase whose expression is essential for the action of TGF-beta. In this paper, we describe the cloning and expression of the human type II TGF-beta promoter. DNA sequence analysis indicates that the region near the transcription initiation site lacks a TATA and CAAT box but contains Sp1 binding sites. A similar promoter type has been identified in the 5' flanking regions of genes that code for certain other growth factor receptors. Transfection of the promoter (888 bp fragment) mediated transcriptional activity in bovine vascular smooth muscle cells and human lung fibroblasts.

Authors+Show Affiliations

Pulmonary Center at Boston University School of Medicine, Massachusetts.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8093019

Citation

Humphries, D E., et al. "Structure and Expression of the Promoter for the Human Type II Transforming Growth Factor-beta Receptor." Biochemical and Biophysical Research Communications, vol. 203, no. 2, 1994, pp. 1020-7.
Humphries DE, Bloom BB, Fine A, et al. Structure and expression of the promoter for the human type II transforming growth factor-beta receptor. Biochem Biophys Res Commun. 1994;203(2):1020-7.
Humphries, D. E., Bloom, B. B., Fine, A., & Goldstein, R. H. (1994). Structure and expression of the promoter for the human type II transforming growth factor-beta receptor. Biochemical and Biophysical Research Communications, 203(2), 1020-7.
Humphries DE, et al. Structure and Expression of the Promoter for the Human Type II Transforming Growth Factor-beta Receptor. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1020-7. PubMed PMID: 8093019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure and expression of the promoter for the human type II transforming growth factor-beta receptor. AU - Humphries,D E, AU - Bloom,B B, AU - Fine,A, AU - Goldstein,R H, PY - 1994/9/15/pubmed PY - 1994/9/15/medline PY - 1994/9/15/entrez SP - 1020 EP - 7 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 203 IS - 2 N2 - The type II TGF-beta receptor is a serine/threonine kinase whose expression is essential for the action of TGF-beta. In this paper, we describe the cloning and expression of the human type II TGF-beta promoter. DNA sequence analysis indicates that the region near the transcription initiation site lacks a TATA and CAAT box but contains Sp1 binding sites. A similar promoter type has been identified in the 5' flanking regions of genes that code for certain other growth factor receptors. Transfection of the promoter (888 bp fragment) mediated transcriptional activity in bovine vascular smooth muscle cells and human lung fibroblasts. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/8093019/Structure_and_expression_of_the_promoter_for_the_human_type_II_transforming_growth_factor_beta_receptor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(84)72284-4 DB - PRIME DP - Unbound Medicine ER -