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Pure seminoma arising in androgen insensitivity syndrome (testicular feminization syndrome): a case report and review of the literature.
Mod Pathol. 1993 Jan; 6(1):89-93.MP

Abstract

This is a case of a young woman who had testicular feminization syndrome and developed a seminoma in an undescended intrapelvic testis. Androgen insensitivity (testicular feminization) syndrome is a rare inherited form of male pseudohermaphroditism that occurs in phenotypically normal women with adequate breast development, normal external genitalia, a vagina of variable depth, absent uterus, and sparse or absent pubic and axillary hair. The gonad (undescended testes) may be intraabdominal, inguinal, or labial. These patients characteristically have male karyotype (XY) and negative sex chromatin and are at increased risk of undergoing malignant transformation of the undescended gonad. We review the literature emphasizing the biochemical and endocrinologic abnormalities leading to the syndrome, as well as the morphologic abnormalities (light microscopic) of the undescended testes, diagnosis, and therapeutic management.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Saint Barnabas Medical Center, Livingston, New Jersey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

8093980

Citation

Collins, G M., et al. "Pure Seminoma Arising in Androgen Insensitivity Syndrome (testicular Feminization Syndrome): a Case Report and Review of the Literature." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 6, no. 1, 1993, pp. 89-93.
Collins GM, Kim DU, Logrono R, et al. Pure seminoma arising in androgen insensitivity syndrome (testicular feminization syndrome): a case report and review of the literature. Mod Pathol. 1993;6(1):89-93.
Collins, G. M., Kim, D. U., Logrono, R., Rickert, R. R., Zablow, A., & Breen, J. L. (1993). Pure seminoma arising in androgen insensitivity syndrome (testicular feminization syndrome): a case report and review of the literature. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 6(1), 89-93.
Collins GM, et al. Pure Seminoma Arising in Androgen Insensitivity Syndrome (testicular Feminization Syndrome): a Case Report and Review of the Literature. Mod Pathol. 1993;6(1):89-93. PubMed PMID: 8093980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pure seminoma arising in androgen insensitivity syndrome (testicular feminization syndrome): a case report and review of the literature. AU - Collins,G M, AU - Kim,D U, AU - Logrono,R, AU - Rickert,R R, AU - Zablow,A, AU - Breen,J L, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 89 EP - 93 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod. Pathol. VL - 6 IS - 1 N2 - This is a case of a young woman who had testicular feminization syndrome and developed a seminoma in an undescended intrapelvic testis. Androgen insensitivity (testicular feminization) syndrome is a rare inherited form of male pseudohermaphroditism that occurs in phenotypically normal women with adequate breast development, normal external genitalia, a vagina of variable depth, absent uterus, and sparse or absent pubic and axillary hair. The gonad (undescended testes) may be intraabdominal, inguinal, or labial. These patients characteristically have male karyotype (XY) and negative sex chromatin and are at increased risk of undergoing malignant transformation of the undescended gonad. We review the literature emphasizing the biochemical and endocrinologic abnormalities leading to the syndrome, as well as the morphologic abnormalities (light microscopic) of the undescended testes, diagnosis, and therapeutic management. SN - 0893-3952 UR - https://www.unboundmedicine.com/medline/citation/8093980/Pure_seminoma_arising_in_androgen_insensitivity_syndrome__testicular_feminization_syndrome_:_a_case_report_and_review_of_the_literature_ L2 - http://www.diseaseinfosearch.org/result/6497 DB - PRIME DP - Unbound Medicine ER -