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Blockade of excitatory amino acid receptors in the ventrolateral medulla does not abolish the cardiovascular actions of L-glutamate.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Jan; 347(1):66-72.NS

Abstract

Injection of L-glutamate into the caudal ventrolateral medulla reduces arterial pressure while injection of L-glutamate into the rostral ventrolateral medulla increases arterial pressure. The present experiments were undertaken to determine whether blockade of excitatory amino acid receptor subtypes in the ventrolateral medulla affects the excitatory action of L-glutamate. In the rabbit and rat caudal ventrolateral medulla, injection of either DL-2-amino-5-phosphonovaleric acid (APV), an N-methyl-D-aspartic acid (NMDA) antagonist, or 6,7-dinitroquinoxaline-2,3-dione (DNQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, increased arterial pressure. Conversely, in the rostral ventrolateral medulla these agents decreased arterial pressure. In the rabbit caudal ventrolateral medulla, injection of APV totally blocked the depressor response to NMDA, and injection of DNQX totally blocked the depressor response to either kainic acid or AMPA. Injection of both APV and DNQX abolished the effects of NMDA, kainic acid and AMPA. However caudal ventrolateral medulla injection of either APV or DNQX, or combined injection of both antagonists, did not affect the relationship between the dose of L-glutamate and the fall in arterial pressure. Similarly, in the rat, combined excitatory amino acid receptor blockade failed to reduce the depressor effect of injected L-glutamate to the caudal ventrolateral medulla. The pressor effect of L-glutamate in the rabbit rostral ventrolateral medulla, when expressed as percentage of baseline level, was unchanged by combined excitatory amino acid receptor blockade.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, Flinders University of South Australia, Bedford Park.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8095325

Citation

Gieroba, Z J., and W W. Blessing. "Blockade of Excitatory Amino Acid Receptors in the Ventrolateral Medulla Does Not Abolish the Cardiovascular Actions of L-glutamate." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 347, no. 1, 1993, pp. 66-72.
Gieroba ZJ, Blessing WW. Blockade of excitatory amino acid receptors in the ventrolateral medulla does not abolish the cardiovascular actions of L-glutamate. Naunyn Schmiedebergs Arch Pharmacol. 1993;347(1):66-72.
Gieroba, Z. J., & Blessing, W. W. (1993). Blockade of excitatory amino acid receptors in the ventrolateral medulla does not abolish the cardiovascular actions of L-glutamate. Naunyn-Schmiedeberg's Archives of Pharmacology, 347(1), 66-72.
Gieroba ZJ, Blessing WW. Blockade of Excitatory Amino Acid Receptors in the Ventrolateral Medulla Does Not Abolish the Cardiovascular Actions of L-glutamate. Naunyn Schmiedebergs Arch Pharmacol. 1993;347(1):66-72. PubMed PMID: 8095325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blockade of excitatory amino acid receptors in the ventrolateral medulla does not abolish the cardiovascular actions of L-glutamate. AU - Gieroba,Z J, AU - Blessing,W W, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 66 EP - 72 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 347 IS - 1 N2 - Injection of L-glutamate into the caudal ventrolateral medulla reduces arterial pressure while injection of L-glutamate into the rostral ventrolateral medulla increases arterial pressure. The present experiments were undertaken to determine whether blockade of excitatory amino acid receptor subtypes in the ventrolateral medulla affects the excitatory action of L-glutamate. In the rabbit and rat caudal ventrolateral medulla, injection of either DL-2-amino-5-phosphonovaleric acid (APV), an N-methyl-D-aspartic acid (NMDA) antagonist, or 6,7-dinitroquinoxaline-2,3-dione (DNQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, increased arterial pressure. Conversely, in the rostral ventrolateral medulla these agents decreased arterial pressure. In the rabbit caudal ventrolateral medulla, injection of APV totally blocked the depressor response to NMDA, and injection of DNQX totally blocked the depressor response to either kainic acid or AMPA. Injection of both APV and DNQX abolished the effects of NMDA, kainic acid and AMPA. However caudal ventrolateral medulla injection of either APV or DNQX, or combined injection of both antagonists, did not affect the relationship between the dose of L-glutamate and the fall in arterial pressure. Similarly, in the rat, combined excitatory amino acid receptor blockade failed to reduce the depressor effect of injected L-glutamate to the caudal ventrolateral medulla. The pressor effect of L-glutamate in the rabbit rostral ventrolateral medulla, when expressed as percentage of baseline level, was unchanged by combined excitatory amino acid receptor blockade.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0028-1298 UR - https://www.unboundmedicine.com/medline/citation/8095325/Blockade_of_excitatory_amino_acid_receptors_in_the_ventrolateral_medulla_does_not_abolish_the_cardiovascular_actions_of_L_glutamate_ DB - PRIME DP - Unbound Medicine ER -