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Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980.
Mov Disord. 1993 Apr; 8(2):195-7.MD

Abstract

The motor effects of the partial dopamine agonist EMD 49980 were evaluated in parkinsonian patients under controlled conditions. EMD 49980 monotherapy resulted in a mild improvement in parkinsonian symptoms, but when co-administered with levodopa, had no significant effect on dyskinesias or on the antiparkinsonian effect of the dopamine precursor. These results suggest that EMD 49980 exerts a net weak dopamine agonist effect but fails to ameliorate levodopa-induced dyskinesias.

Authors+Show Affiliations

Bravi D
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Davis TL
No affiliation info available
Mouradian MM
No affiliation info available
Chase TN
No affiliation info available

MeSH

AdultBrainDopamine AgentsDouble-Blind MethodDyskinesia, Drug-InducedFemaleHumansIndolesLevodopaMaleMiddle AgedNeurologic ExaminationOxindolesParkinson DiseasePyridinesReceptors, Dopamine

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8097280

Citation

Bravi, D, et al. "Treatment of Parkinson's Disease With the Partial Dopamine Agonist EMD 49980." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 8, no. 2, 1993, pp. 195-7.
Bravi D, Davis TL, Mouradian MM, et al. Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980. Mov Disord. 1993;8(2):195-7.
Bravi, D., Davis, T. L., Mouradian, M. M., & Chase, T. N. (1993). Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980. Movement Disorders : Official Journal of the Movement Disorder Society, 8(2), 195-7.
Bravi D, et al. Treatment of Parkinson's Disease With the Partial Dopamine Agonist EMD 49980. Mov Disord. 1993;8(2):195-7. PubMed PMID: 8097280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980. AU - Bravi,D, AU - Davis,T L, AU - Mouradian,M M, AU - Chase,T N, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 195 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 8 IS - 2 N2 - The motor effects of the partial dopamine agonist EMD 49980 were evaluated in parkinsonian patients under controlled conditions. EMD 49980 monotherapy resulted in a mild improvement in parkinsonian symptoms, but when co-administered with levodopa, had no significant effect on dyskinesias or on the antiparkinsonian effect of the dopamine precursor. These results suggest that EMD 49980 exerts a net weak dopamine agonist effect but fails to ameliorate levodopa-induced dyskinesias. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8097280/Treatment_of_Parkinson's_disease_with_the_partial_dopamine_agonist_EMD_49980_ L2 - https://doi.org/10.1002/mds.870080214 DB - PRIME DP - Unbound Medicine ER -