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Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis.

Abstract

Treatment of atopic dermatitis with essential fatty acids remains controversial. A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Dermatology, Leicester Royal Infirmary, UK.

    Source

    Lancet (London, England) 341:8860 1993 Jun 19 pg 1557-60

    MeSH

    Adult
    Anti-Inflammatory Agents, Non-Steroidal
    Dermatitis, Atopic
    Double-Blind Method
    Drug Therapy, Combination
    Fatty Acids, Essential
    Female
    Fish Oils
    Humans
    Linoleic Acids
    Male
    Plant Oils
    gamma-Linolenic Acid

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    8099640

    Citation

    Berth-Jones, J, and R A. Graham-Brown. "Placebo-controlled Trial of Essential Fatty Acid Supplementation in Atopic Dermatitis." Lancet (London, England), vol. 341, no. 8860, 1993, pp. 1557-60.
    Berth-Jones J, Graham-Brown RA. Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. Lancet. 1993;341(8860):1557-60.
    Berth-Jones, J., & Graham-Brown, R. A. (1993). Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. Lancet (London, England), 341(8860), pp. 1557-60.
    Berth-Jones J, Graham-Brown RA. Placebo-controlled Trial of Essential Fatty Acid Supplementation in Atopic Dermatitis. Lancet. 1993 Jun 19;341(8860):1557-60. PubMed PMID: 8099640.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. AU - Berth-Jones,J, AU - Graham-Brown,R A, PY - 1993/6/19/pubmed PY - 1993/6/19/medline PY - 1993/6/19/entrez SP - 1557 EP - 60 JF - Lancet (London, England) JO - Lancet VL - 341 IS - 8860 N2 - Treatment of atopic dermatitis with essential fatty acids remains controversial. A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/8099640/Placebo_controlled_trial_of_essential_fatty_acid_supplementation_in_atopic_dermatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0140-6736(93)90697-F DB - PRIME DP - Unbound Medicine ER -